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Sclerostin inhibition reverses systemic, periarticular and local bone loss in arthritis

OBJECTIVE: To test whether inhibition of sclerostin by a targeted monoclonal antibody (Scl-Ab) protects from bone and cartilage damage in inflammatory arthritis. Sclerostin is a potent inhibitor of bone formation and may be responsible for the low level of bone repair in patients with rheumatoid art...

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Detalles Bibliográficos
Autores principales:	Chen, Xiao-Xiang, Baum, Wolfgang, Dwyer, Denise, Stock, Michael, Schwabe, Kay, Ke, Hua-Zhu, Stolina, Marina, Schett, Georg, Bozec, Aline
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2013
Materias:	Basic and Translational Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3786639/ https://www.ncbi.nlm.nih.gov/pubmed/23666928 http://dx.doi.org/10.1136/annrheumdis-2013-203345

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