GARP Is Regulated by miRNAs and Controls Latent TGF-β1 Production by Human Regulatory T Cells

GARP is a transmembrane protein present on stimulated human regulatory T lymphocytes (Tregs), but not on other T lymphocytes (Th cells). It presents the latent form of TGF-β1 on the Treg surface. We report here that GARP favors the cleavage of the pro-TGF-β1 precursor and increases the amount of sec...

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Detalles Bibliográficos
Autores principales: Gauthy, Emilie, Cuende, Julia, Stockis, Julie, Huygens, Caroline, Lethé, Bernard, Collet, Jean-François, Bommer, Guido, Coulie, Pierre G., Lucas, Sophie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787020/
https://www.ncbi.nlm.nih.gov/pubmed/24098777
http://dx.doi.org/10.1371/journal.pone.0076186

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