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High Resolution Crystal Structure of the Grb2 SH2 Domain with a Phosphopeptide Derived from CD28

Src homology 2 (SH2) domains play a critical role in cellular signal transduction. They bind to peptides containing phosphotyrosine (pY) with various specificities that depend on the flanking amino-acid residues. The SH2 domain of growth-factor receptor-bound protein 2 (Grb2) specifically recognizes...

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Detalles Bibliográficos
Autores principales:	Higo, Kunitake, Ikura, Teikichi, Oda, Masayuki, Morii, Hisayuki, Takahashi, Jun, Abe, Ryo, Ito, Nobutoshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787023/ https://www.ncbi.nlm.nih.gov/pubmed/24098653 http://dx.doi.org/10.1371/journal.pone.0074482

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