Cargando…

Targeting p35/Cdk5 Signalling via CIP-Peptide Promotes Angiogenesis in Hypoxia

Cyclin-dependent kinase-5 (Cdk5) is over-expressed in both neurons and microvessels in hypoxic regions of stroke tissue and has a significant pathological role following hyper-phosphorylation leading to calpain-induced cell death. Here, we have identified a critical role of Cdk5 in cytoskeleton/foca...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bosutti, Alessandra, Qi, Jie, Pennucci, Roberta, Bolton, David, Matou, Sabine, Ali, Kamela, Tsai, Li-Huei, Krupinski, Jerzy, Petcu, Eugene B., Montaner, Joan, Al Baradie, Raid, Caccuri, Francesca, Caruso, Arnaldo, Alessandri, Giulio, Kumar, Shant, Rodriguez, Cristina, Martinez-Gonzalez, Jose, Slevin, Mark
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787057/ https://www.ncbi.nlm.nih.gov/pubmed/24098701 http://dx.doi.org/10.1371/journal.pone.0075538

Ejemplares similares

Mesenchymal Stem Cells Loaded with p5, Derived from CDK5 Activator p35, Inhibit Calcium-Induced CDK5 Activation in Endothelial Cells
por: Fang, Wen-Hui, et al.
Publicado: (2016)

Citicoline induces angiogenesis improving survival of vascular/human brain microvessel endothelial cells through pathways involving ERK1/2 and insulin receptor substrate-1
por: Krupinski, Jerzy, et al.
Publicado: (2012)

A microarray study of gene and protein regulation in human and rat brain following middle cerebral artery occlusion
por: Mitsios, Nick, et al.
Publicado: (2007)

Pax genes in embryogenesis and oncogenesis
por: Wang, Qiuyu, et al.
Publicado: (2008)

DNA Methylation in Stroke. Update of Latest Advances
por: Krupinski, Jerzy, et al.
Publicado: (2017)

Monomeric C-reactive protein-a key molecule driving development of Alzheimer’s disease associated with brain ischaemia?
por: Slevin, M., et al.
Publicado: (2015)

Endothelial cells are major players in SARS-CoV-2-related acute respiratory distress syndrome
por: Caccuri, Francesca, et al.
Publicado: (2022)

An analysis of the regulation of DNA synthesis by cdk2, Cip1, and licensing factor
Publicado: (1995)

Emerging Molecular Targets for Brain Repair after Stroke
por: Krupinski, Jerzy, et al.
Publicado: (2013)

Proteolysis of Xenopus Cip-type CDK inhibitor, p16(Xic2), is regulated by PCNA binding and CDK2 phosphorylation
por: Zhu, Xi-Ning, et al.
Publicado: (2013)

(123)I-FP-CIT SPECT imaging in early diagnosis of dementia in patients with and without a vascular component
por: Garriga, Marina, et al.
Publicado: (2015)

Viral Proteins as Emerging Cancer Therapeutics
por: Manocha, Ekta, et al.
Publicado: (2021)

C-reactive protein exerts angiogenic effects on vascular endothelial cells and modulates associated signalling pathways and gene expression
por: Turu, Marta M, et al.
Publicado: (2008)

Controlling the angiogenic switch in developing atherosclerotic plaques: Possible targets for therapeutic intervention
por: Slevin, Mark, et al.
Publicado: (2009)

HIV-1 matrix protein p17 misfolding forms toxic amyloidogenic assemblies that induce neurocognitive disorders
por: Zeinolabediny, Yasmin, et al.
Publicado: (2017)

Nanotechnology for the treatment of coronary in stent restenosis: a clinical perspective
por: McDowell, Garry, et al.
Publicado: (2011)

Avian Reovirus P17 Suppresses Angiogenesis by Promoting DPP4 Secretion
por: Manocha, Ekta, et al.
Publicado: (2021)

Synthetic HIV-1 matrix protein p17-based AT20-KLH therapeutic immunization in HIV-1-infected patients receiving antiretroviral treatment: A phase I safety and immunogenicity study
por: Caruso, Arnaldo, et al.
Publicado: (2014)

Serosurvey in BNT162b2 vaccine-elicited neutralizing antibodies against authentic B.1, B.1.1.7, B.1.351, B.1.525 and P.1 SARS-CoV-2 variants
por: Zani, Alberto, et al.
Publicado: (2021)

Binding to PI(4,5)P(2) is indispensable for secretion of B-cell clonogenic HIV-1 matrix protein p17 variants
por: Bugatti, Antonella, et al.
Publicado: (2021)

Human Herpesvirus 6A and 6B inhibit in vitro angiogenesis by induction of Human Leukocyte Antigen G
por: Rizzo, Roberta, et al.
Publicado: (2018)

Role of Autophagy in Von Willebrand Factor Secretion by Endothelial Cells and in the In Vivo Thrombin-Antithrombin Complex Formation Promoted by the HIV-1 Matrix Protein p17
por: Bugatti, Antonella, et al.
Publicado: (2020)

Knockdown of Expression of Cdk5 or p35 (a Cdk5 Activator) Results in Podocyte Apoptosis
por: Zheng, Ya-Li, et al.
Publicado: (2016)

The first Italian outbreak of SARS‐CoV‐2 B.1.1.7 lineage in Corzano, Lombardy
por: Messali, Serena, et al.
Publicado: (2021)

Cdk5 Inhibitory Peptide (CIP) Inhibits Cdk5/p25 Activity Induced by High Glucose in Pancreatic Beta Cells and Recovers Insulin Secretion from p25 Damage
por: Zheng, Ya-Li, et al.
Publicado: (2013)

Effects of p35 Mutations Associated with Mental Retardation on the Cellular Function of p35-CDK5
por: Takada, Shunsuke, et al.
Publicado: (2015)

Human and mouse brain-derived endothelial cells require high levels of growth factors medium for their isolation, in vitro maintenance and survival
por: Navone, Stefania Elena, et al.
Publicado: (2013)

p27(Kip1) and p21(Cip1) collaborate in the regulation of transcription by recruiting cyclin–Cdk complexes on the promoters of target genes
por: Orlando, Serena, et al.
Publicado: (2015)

Yeast Cip1 is activated by environmental stress to inhibit Cdk1–G1 cyclins via Mcm1 and Msn2/4
por: Chang, Ya-Lan, et al.
Publicado: (2017)

Mycoplasma infection may complicate the clinical course of SARS-Co-V-2 associated Kawasaki-like disease in children
por: Plebani, Alessandro, et al.
Publicado: (2020)

First detection of SARS-CoV-2 spike protein N501 mutation in Italy in August, 2020
por: Fiorentini, Simona, et al.
Publicado: (2021)

Monomeric C-Reactive Protein Aggravates Secondary Degeneration after Intracerebral Haemorrhagic Stroke and May Function as a Sensor for Systemic Inflammation
por: Slevin, Mark, et al.
Publicado: (2020)

The CDK inhibitor p21(Cip1/WAF1 )is induced by FcγR activation and restricts HIV-1 replication in human macrophages
por: Bergamaschi, Anna, et al.
Publicado: (2009)

6-Methoxyflavone induces S-phase arrest through the CCNA2/CDK2/p21CIP1 signaling pathway in HeLa cells
por: Zhang, Chaihong, et al.
Publicado: (2022)

Protective role of cytoplasmic p21Cip1/Waf1 in apoptosis of CDK4/6 inhibitor‐induced senescence in breast cancer cells
por: Kartika, Irna D., et al.
Publicado: (2021)

Effects of Carbonyl Iron Powder (CIP) Content on the Electromagnetic Wave Absorption and Mechanical Properties of CIP/ABS Composites
por: Lai, Wenwen, et al.
Publicado: (2020)

Resveratrol inhibits Cdk5 activity through regulation of p35 expression
por: Utreras, Elias, et al.
Publicado: (2011)

CD105 positive neovessels are prevalent in early stage carotid lesions, and correlate with the grade in more advanced carotid and coronary plaques
por: Luque, Ana, et al.
Publicado: (2009)

FoxF1 and FoxF2 transcription factors synergistically promote Rhabdomyosarcoma carcinogenesis by repressing transcription of p21(Cip1) CDK inhibitor
por: Milewski, David, et al.
Publicado: (2016)

The Cyclin-Dependent Kinase 5 Inhibitor Peptide Inhibits Herpes Simplex Virus Type 1 Replication
por: Man, Adrian, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_49ntvrugl0cv1ku72tcin5fbq8