Combining TRAIL with PI3 Kinase or HSP90 inhibitors enhances apoptosis in colorectal cancer cells via suppression of survival signaling

TRAIL has been shown to induce apoptosis in cancer cells, but in some cases they fail to respond to this ligand. We explored the ability of representative phosphatidylinositol-3-kinase (PI3 Kinase)/mTOR and HSP90 inhibitors to overcome TRAIL resistance by increasing apoptosis in colorectal cancer mo...

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Detalles Bibliográficos
Autores principales: Saturno, Grazia, Valenti, Melanie, De Haven Brandon, Alexis, Thomas, George V., Eccles, Suzanne, Clarke, Paul A., Workman, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2013
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787150/
https://www.ncbi.nlm.nih.gov/pubmed/23852390

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787150/
https://www.ncbi.nlm.nih.gov/pubmed/23852390

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