Tumor Delivery of Chemotherapy Combined with Inhibitors of Angiogenesis and Vascular Targeting Agents

Numerous angiogenesis-vascular targeting agents have been admitted to the ranks of cancer therapeutics; most are used in polytherapy regimens. This review looks at recent progress and our own preclinical experience in combining angiogenesis inhibitors, mainly acting on VEGF/VEGFR pathways, and vascu...

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Autores principales: Cesca, Marta, Bizzaro, Francesca, Zucchetti, Massimo, Giavazzi, Raffaella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787308/
https://www.ncbi.nlm.nih.gov/pubmed/24102047
http://dx.doi.org/10.3389/fonc.2013.00259
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author Cesca, Marta
Bizzaro, Francesca
Zucchetti, Massimo
Giavazzi, Raffaella
author_facet Cesca, Marta
Bizzaro, Francesca
Zucchetti, Massimo
Giavazzi, Raffaella
author_sort Cesca, Marta
collection PubMed
description Numerous angiogenesis-vascular targeting agents have been admitted to the ranks of cancer therapeutics; most are used in polytherapy regimens. This review looks at recent progress and our own preclinical experience in combining angiogenesis inhibitors, mainly acting on VEGF/VEGFR pathways, and vascular targeting agents with conventional chemotherapy, discussing the factors that determine the outcome of these treatments. Molecular and morphological modifications of the tumor microenvironment associated with drug distribution and activity are reviewed. Modalities to improve drug delivery and strategies for optimizing combination therapy are examined.
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spelling pubmed-37873082013-10-07 Tumor Delivery of Chemotherapy Combined with Inhibitors of Angiogenesis and Vascular Targeting Agents Cesca, Marta Bizzaro, Francesca Zucchetti, Massimo Giavazzi, Raffaella Front Oncol Oncology Numerous angiogenesis-vascular targeting agents have been admitted to the ranks of cancer therapeutics; most are used in polytherapy regimens. This review looks at recent progress and our own preclinical experience in combining angiogenesis inhibitors, mainly acting on VEGF/VEGFR pathways, and vascular targeting agents with conventional chemotherapy, discussing the factors that determine the outcome of these treatments. Molecular and morphological modifications of the tumor microenvironment associated with drug distribution and activity are reviewed. Modalities to improve drug delivery and strategies for optimizing combination therapy are examined. Frontiers Media S.A. 2013-10-01 /pmc/articles/PMC3787308/ /pubmed/24102047 http://dx.doi.org/10.3389/fonc.2013.00259 Text en Copyright © 2013 Cesca, Bizzaro, Zucchetti and Giavazzi. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Cesca, Marta
Bizzaro, Francesca
Zucchetti, Massimo
Giavazzi, Raffaella
Tumor Delivery of Chemotherapy Combined with Inhibitors of Angiogenesis and Vascular Targeting Agents
title Tumor Delivery of Chemotherapy Combined with Inhibitors of Angiogenesis and Vascular Targeting Agents
title_full Tumor Delivery of Chemotherapy Combined with Inhibitors of Angiogenesis and Vascular Targeting Agents
title_fullStr Tumor Delivery of Chemotherapy Combined with Inhibitors of Angiogenesis and Vascular Targeting Agents
title_full_unstemmed Tumor Delivery of Chemotherapy Combined with Inhibitors of Angiogenesis and Vascular Targeting Agents
title_short Tumor Delivery of Chemotherapy Combined with Inhibitors of Angiogenesis and Vascular Targeting Agents
title_sort tumor delivery of chemotherapy combined with inhibitors of angiogenesis and vascular targeting agents
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787308/
https://www.ncbi.nlm.nih.gov/pubmed/24102047
http://dx.doi.org/10.3389/fonc.2013.00259
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