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Synaptic mutant huntingtin inhibits synapsin-1 phosphorylation and causes neurological symptoms

Many genetic mouse models of Huntington’s disease (HD) have established that mutant huntingtin (htt) accumulates in various subcellular regions to affect a variety of cellular functions, but whether and how synaptic mutant htt directly mediates HD neuropathology remains to be determined. We generate...

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Detalles Bibliográficos
Autores principales:	Xu, Qiaoqiao, Huang, Shanshan, Song, Mingke, Wang, Chuan-En, Yan, Sen, Liu, Xudong, Gaertig, Marta A., Yu, Shan Ping, Li, He, Li, Shihua, Li, Xiao-Jiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2013
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787372/ https://www.ncbi.nlm.nih.gov/pubmed/24081492 http://dx.doi.org/10.1083/jcb.201303146

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