Activation of the Interferon Pathway is Dependent Upon Autoantibodies in African-American SLE Patients, but Not in European-American SLE Patients

Background: In systemic lupus erythematosus (SLE), antibodies directed at RNA-binding proteins (anti-RBP) are associated with high serum type I interferon (IFN), which plays an important role in SLE pathogenesis. African-Americans (AA) are more likely to develop SLE, and SLE is also more severe in t...

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Detalles Bibliográficos
Autores principales: Ko, Kichul, Koldobskaya, Yelena, Rosenzweig, Elizabeth, Niewold, Timothy B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787392/
https://www.ncbi.nlm.nih.gov/pubmed/24101921
http://dx.doi.org/10.3389/fimmu.2013.00309

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