Cargando…

Sodium overload due to a persistent current that attenuates the arrhythmogenic potential of a novel LQT3 mutation

Long QT syndrome (LQTS) is a congenital abnormality of cardiac repolarization that manifests as a prolonged QT interval on 12-lead electrocardiograms (ECGs). The syndrome may lead to syncope and sudden death from ventricular tachyarrhythmias known as torsades de pointes. An increased persistent Na(+...

Descripción completa

Detalles Bibliográficos
Autores principales:	Moreau, Adrien, Krahn, Andrew D., Gosselin-Badaroudine, Pascal, Klein, George J., Christé, Georges, Vincent, Yohann, Boutjdir, Mohamed, Chahine, Mohamed
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2013
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787509/ https://www.ncbi.nlm.nih.gov/pubmed/24098284 http://dx.doi.org/10.3389/fphar.2013.00126

Ejemplares similares

Mutations in the Voltage Sensors of Domains I and II of Na(v)1.5 that are Associated with Arrhythmias and Dilated Cardiomyopathy Generate Gating Pore Currents
por: Moreau, Adrien, et al.
Publicado: (2015)

Biophysics, pathophysiology, and pharmacology of ion channel gating pores
por: Moreau, Adrien, et al.
Publicado: (2014)

Gating pore currents, a new pathological mechanism underlying cardiac arrhythmias associated with dilated cardiomyopathy
por: Moreau, Adrien, et al.
Publicado: (2015)

A leaky voltage sensor domain of cardiac sodium channels causes arrhythmias associated with dilated cardiomyopathy
por: Moreau, Adrien, et al.
Publicado: (2018)

Gating pore currents are defects in common with two Na(v)1.5 mutations in patients with mixed arrhythmias and dilated cardiomyopathy
por: Moreau, Adrien, et al.
Publicado: (2015)

Biophysical characterization of the honeybee DSC1 orthologue reveals a novel voltage-dependent Ca(2+) channel subfamily: Ca(V)4
por: Gosselin-Badaroudine, Pascal, et al.
Publicado: (2016)

Characterization of the honeybee AmNa(V)1 channel and tools to assess the toxicity of insecticides
por: Gosselin-Badaroudine, Pascal, et al.
Publicado: (2015)

A Proton Leak Current through the Cardiac Sodium Channel Is Linked to Mixed Arrhythmia and the Dilated Cardiomyopathy Phenotype
por: Gosselin-Badaroudine, Pascal, et al.
Publicado: (2012)

Correction: A Proton Leak Current through the Cardiac Sodium Channel Is Linked to Mixed Arrhythmia and the Dilated Cardiomyopathy Phenotype
por: Gosselin-Badaroudine, Pascal, et al.
Publicado: (2012)

Transgenic LQT2, LQT5, and LQT2‐5 rabbit models with decreased repolarisation reserve for prediction of drug‐induced ventricular arrhythmias
por: Hornyik, Tibor, et al.
Publicado: (2020)

Propranolol prevents life-threatening arrhythmias in LQT3 transgenic mice: Implications for the clinical management of LQT3 patients()
por: Calvillo, Laura, et al.
Publicado: (2014)

Substitutions of the S4DIV R2 residue (R1451) in Na(V)1.4 lead to complex forms of paramyotonia congenita and periodic paralyses
por: Poulin, Hugo, et al.
Publicado: (2018)

Arrhythmogenic cardiomyopathy as a myogenic disease: highlights from cardiomyocytes derived from human induced pluripotent stem cells
por: Reisqs, J. B., et al.
Publicado: (2023)

Racial Disparities in Ion Channelopathies and Inherited Cardiovascular Diseases Associated With Sudden Cardiac Death
por: Chahine, Mohamed, et al.
Publicado: (2022)

Cardiac involvement in patient-specific induced pluripotent stem cells of myotonic dystrophy type 1: unveiling the impact of voltage-gated sodium channels
por: Pierre, Marion, et al.
Publicado: (2023)

Relationship between KCNQ1 (LQT1) and KCNH2 (LQT2) gene mutations and sudden death during illegal drug use
por: Nagasawa, Sayaka, et al.
Publicado: (2018)

A New Cardiac Channelopathy: From Clinical Phenotypes to Molecular Mechanisms Associated With Na(v)1.5 Gating Pores
por: Moreau, Adrien, et al.
Publicado: (2018)

Optical Mapping of Cardiomyocytes in Monolayer Derived from Induced Pluripotent Stem Cells
por: Djemai, Mohammed, et al.
Publicado: (2023)

Linkage Evidence for a Two-Locus Inheritance of LQT-Associated Seizures in a Multigenerational LQT Family With a Novel KCNQ1 Loss-of-Function Mutation
por: Prüss, Harald, et al.
Publicado: (2019)

Differential diagnosis between LQT1 and LQT2 by QT/RR relationships using 24‐hour Holter monitoring: A multicenter cross‐sectional study
por: Yodogawa, Kenji, et al.
Publicado: (2021)

Ethnic and racial differences in Asian populations with ion channelopathies associated with sudden cardiac death
por: Zaveri, Sahil, et al.
Publicado: (2023)

Pathophysiology of Ca(v)1.3 L-type calcium channels in the heart
por: Zaveri, Sahil, et al.
Publicado: (2023)

Sudden Death of Cardiac Origin and Psychotropic Drugs
por: Timour, Quadiri, et al.
Publicado: (2012)

Candesartan Cilexetil Attenuates Arrhythmogenicity Following Pressure Overload in Rats via the Modulation of Cardiac Electrical and Structural Remodeling and Calcium Handling Dysfunction
por: Chang, Gwo‐Jyh, et al.
Publicado: (2022)

Short QT interval as a harbinger of an arrhythmogenic cardiomyopathy
por: Chevalier, Philippe, et al.
Publicado: (2021)

Mexiletine Treatment for Neonatal LQT3 Syndrome: Case Report and Literature Review
por: Bagkaki, Alena, et al.
Publicado: (2021)

Arrhythmogenic mechanisms of interleukin-6 combination with hydroxychloroquine and azithromycin in inflammatory diseases
por: Zhu, Xiaojia, et al.
Publicado: (2022)

A rare association of long QT syndrome and syndactyly: Timothy Syndrome (LQT 8)
por: Krause, U., et al.
Publicado: (2011)

High prevalence of genetic variants previously associated with LQT syndrome in new exome data
por: Refsgaard, Lena, et al.
Publicado: (2012)

Characterization of a novel LQT3 variant with a selective efficacy of mexiletine treatment
por: Kim, Hyun-Ji, et al.
Publicado: (2019)

Vicious LQT induced by a combination of factors different from hERG inhibition
por: Xu, Xinping, et al.
Publicado: (2022)

New Insights into Cardiac and Brain Sodium Channels Modulation by Beta Blockers
por: Chahine, Mohamed
Publicado: (2011)

Mechanistic basis for LQT1 caused by S3 mutations in the KCNQ1 subunit of I(Ks)
por: Eldstrom, Jodene, et al.
Publicado: (2010)

Functional study of a KCNH2 mutant: Novel insights on the pathogenesis of the LQT2 syndrome
por: De Zio, Roberta, et al.
Publicado: (2019)

Recent Progress and Challenges in the Development of Antisense Therapies for Myotonic Dystrophy Type 1
por: De Serres-Bérard, Thiéry, et al.
Publicado: (2022)

iPSC-derived cardiomyocytes from patients with myotonic dystrophy type 1 have abnormal ion channel functions and slower conduction velocities
por: Poulin, Hugo, et al.
Publicado: (2021)

Changes in Channel Trafficking and Protein Stability Caused by LQT2 Mutations in the PAS Domain of the HERG Channel
por: Harley, Carol A., et al.
Publicado: (2012)

Disruption of a Conservative Motif in the C-Terminal Loop of the KCNQ1 Channel Causes LQT Syndrome
por: Karlova, Maria, et al.
Publicado: (2022)

Recent advances in voltage-gated sodium channels, their pharmacology, and related diseases
por: Desaphy, Jean-François, et al.
Publicado: (2013)

Mexiletine rescues a mixed biophysical phenotype of the cardiac sodium channel arising from the SCN5A mutation, N406K, found in LQT3 patients
por: Hu, Rou-Mu, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_imvler87li8aapnfpq4thp6gd6