Cargando…

In-Vivo Effect of Andrographolide on Alveolar Bone Resorption Induced by Porphyromonas gingivalis and Its Relation with Antioxidant Enzymes

Alveolar bone resorption is one of the most important facts in denture construction. Porphyromonas gingivalis (Pg) causes alveolar bone resorption, and morphologic measurements are the most frequent methods to identify bone resorption in periodontal studies. This study has aimed at evaluating the ef...

Descripción completa

Detalles Bibliográficos
Autores principales: Al Batran, Rami, Al-Bayaty, Fouad H., Al-Obaidi, Mazen M. Jamil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787561/
https://www.ncbi.nlm.nih.gov/pubmed/24151590
http://dx.doi.org/10.1155/2013/276329
_version_ 1782286192519151616
author Al Batran, Rami
Al-Bayaty, Fouad H.
Al-Obaidi, Mazen M. Jamil
author_facet Al Batran, Rami
Al-Bayaty, Fouad H.
Al-Obaidi, Mazen M. Jamil
author_sort Al Batran, Rami
collection PubMed
description Alveolar bone resorption is one of the most important facts in denture construction. Porphyromonas gingivalis (Pg) causes alveolar bone resorption, and morphologic measurements are the most frequent methods to identify bone resorption in periodontal studies. This study has aimed at evaluating the effect of Andrographolide (AND) on alveolar bone resorption in rats induced by Pg. 24 healthy male Sprague Dawley rats were divided into four groups as follows: normal control group and three experimental groups challenged orally with Pg ATCC 33277 five times a week supplemented with 20 mg/kg and 10 mg/kg of AND for twelve weeks. Alveolar bones of the left and right sides of the mandible were assessed by a morphometric method. The bone level, that is, the distance from the alveolar bone crest to cementumenamel junction (CEJ), was measured using 6.1 : 1 zoom stereomicroscope and software. AND reduced the effect of Pg on alveolar bone resorption and decreased the serum levels of Hexanoyl-Lysine (HEL); furthermore the reduced glutathione/oxidised glutathione (GSH/GSSG) ratio in AND treated groups (10 and 20 mg/kg) significantly increased when compared with the Pg group (P < 0.05). We can conclude that AND suppresses alveolar bone resorption caused by Pg in rats.
format Online
Article
Text
id pubmed-3787561
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-37875612013-10-22 In-Vivo Effect of Andrographolide on Alveolar Bone Resorption Induced by Porphyromonas gingivalis and Its Relation with Antioxidant Enzymes Al Batran, Rami Al-Bayaty, Fouad H. Al-Obaidi, Mazen M. Jamil Biomed Res Int Research Article Alveolar bone resorption is one of the most important facts in denture construction. Porphyromonas gingivalis (Pg) causes alveolar bone resorption, and morphologic measurements are the most frequent methods to identify bone resorption in periodontal studies. This study has aimed at evaluating the effect of Andrographolide (AND) on alveolar bone resorption in rats induced by Pg. 24 healthy male Sprague Dawley rats were divided into four groups as follows: normal control group and three experimental groups challenged orally with Pg ATCC 33277 five times a week supplemented with 20 mg/kg and 10 mg/kg of AND for twelve weeks. Alveolar bones of the left and right sides of the mandible were assessed by a morphometric method. The bone level, that is, the distance from the alveolar bone crest to cementumenamel junction (CEJ), was measured using 6.1 : 1 zoom stereomicroscope and software. AND reduced the effect of Pg on alveolar bone resorption and decreased the serum levels of Hexanoyl-Lysine (HEL); furthermore the reduced glutathione/oxidised glutathione (GSH/GSSG) ratio in AND treated groups (10 and 20 mg/kg) significantly increased when compared with the Pg group (P < 0.05). We can conclude that AND suppresses alveolar bone resorption caused by Pg in rats. Hindawi Publishing Corporation 2013 2013-09-17 /pmc/articles/PMC3787561/ /pubmed/24151590 http://dx.doi.org/10.1155/2013/276329 Text en Copyright © 2013 Rami Al Batran et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Al Batran, Rami
Al-Bayaty, Fouad H.
Al-Obaidi, Mazen M. Jamil
In-Vivo Effect of Andrographolide on Alveolar Bone Resorption Induced by Porphyromonas gingivalis and Its Relation with Antioxidant Enzymes
title In-Vivo Effect of Andrographolide on Alveolar Bone Resorption Induced by Porphyromonas gingivalis and Its Relation with Antioxidant Enzymes
title_full In-Vivo Effect of Andrographolide on Alveolar Bone Resorption Induced by Porphyromonas gingivalis and Its Relation with Antioxidant Enzymes
title_fullStr In-Vivo Effect of Andrographolide on Alveolar Bone Resorption Induced by Porphyromonas gingivalis and Its Relation with Antioxidant Enzymes
title_full_unstemmed In-Vivo Effect of Andrographolide on Alveolar Bone Resorption Induced by Porphyromonas gingivalis and Its Relation with Antioxidant Enzymes
title_short In-Vivo Effect of Andrographolide on Alveolar Bone Resorption Induced by Porphyromonas gingivalis and Its Relation with Antioxidant Enzymes
title_sort in-vivo effect of andrographolide on alveolar bone resorption induced by porphyromonas gingivalis and its relation with antioxidant enzymes
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787561/
https://www.ncbi.nlm.nih.gov/pubmed/24151590
http://dx.doi.org/10.1155/2013/276329
work_keys_str_mv AT albatranrami invivoeffectofandrographolideonalveolarboneresorptioninducedbyporphyromonasgingivalisanditsrelationwithantioxidantenzymes
AT albayatyfouadh invivoeffectofandrographolideonalveolarboneresorptioninducedbyporphyromonasgingivalisanditsrelationwithantioxidantenzymes
AT alobaidimazenmjamil invivoeffectofandrographolideonalveolarboneresorptioninducedbyporphyromonasgingivalisanditsrelationwithantioxidantenzymes