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Mycobacterial Dormancy Regulon Protein Rv2623 as a Novel Biomarker for the Diagnosis of Latent and Active Tuberculous Meningitis

The present study was designed to investigate Rv2623 antigen, a major dormancy regulon protein of Mycobacterium tuberculosis (MTB) in CSF of suspected latent and active tuberculous meningitis (TBM) patients. A total of 100 CSF samples from TBM (n = 31), suspected latent TBM (n = 22), and suitable no...

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Autores principales: Jain, Ruchika K., Nayak, Amit R., Husain, Aliabbas A., Panchbhai, Milind S., Chandak, Nitin, Purohit, Hemant J., Taori, Girdhar M., Daginawala, Hatim F., Kashyap, Rajpal S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787564/
https://www.ncbi.nlm.nih.gov/pubmed/24167379
http://dx.doi.org/10.1155/2013/309816
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author Jain, Ruchika K.
Nayak, Amit R.
Husain, Aliabbas A.
Panchbhai, Milind S.
Chandak, Nitin
Purohit, Hemant J.
Taori, Girdhar M.
Daginawala, Hatim F.
Kashyap, Rajpal S.
author_facet Jain, Ruchika K.
Nayak, Amit R.
Husain, Aliabbas A.
Panchbhai, Milind S.
Chandak, Nitin
Purohit, Hemant J.
Taori, Girdhar M.
Daginawala, Hatim F.
Kashyap, Rajpal S.
author_sort Jain, Ruchika K.
collection PubMed
description The present study was designed to investigate Rv2623 antigen, a major dormancy regulon protein of Mycobacterium tuberculosis (MTB) in CSF of suspected latent and active tuberculous meningitis (TBM) patients. A total of 100 CSF samples from TBM (n = 31), suspected latent TBM (n = 22), and suitable noninfectious control subjects (n = 47) were collected and evaluated for Rv2623 antigen level using ELISA protocol. A significantly high (P < 0.05) mean absorbance was observed in samples of suspected latent TBM and active TBM patients as compared to non-TBM control patients. However, no significant difference in Rv2623 level was observed between suspected latent TBM and TBM patients. Our preliminary findings suggest that Rv2623 may be useful as a potential biomarker for the diagnosis of the latent as well as active TBM infection. Futher evaluation of this biomarker in large number of samples is therefore needed to confirm the result.
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spelling pubmed-37875642013-10-09 Mycobacterial Dormancy Regulon Protein Rv2623 as a Novel Biomarker for the Diagnosis of Latent and Active Tuberculous Meningitis Jain, Ruchika K. Nayak, Amit R. Husain, Aliabbas A. Panchbhai, Milind S. Chandak, Nitin Purohit, Hemant J. Taori, Girdhar M. Daginawala, Hatim F. Kashyap, Rajpal S. Dis Markers Research Article The present study was designed to investigate Rv2623 antigen, a major dormancy regulon protein of Mycobacterium tuberculosis (MTB) in CSF of suspected latent and active tuberculous meningitis (TBM) patients. A total of 100 CSF samples from TBM (n = 31), suspected latent TBM (n = 22), and suitable noninfectious control subjects (n = 47) were collected and evaluated for Rv2623 antigen level using ELISA protocol. A significantly high (P < 0.05) mean absorbance was observed in samples of suspected latent TBM and active TBM patients as compared to non-TBM control patients. However, no significant difference in Rv2623 level was observed between suspected latent TBM and TBM patients. Our preliminary findings suggest that Rv2623 may be useful as a potential biomarker for the diagnosis of the latent as well as active TBM infection. Futher evaluation of this biomarker in large number of samples is therefore needed to confirm the result. Hindawi Publishing Corporation 2013 2013-09-15 /pmc/articles/PMC3787564/ /pubmed/24167379 http://dx.doi.org/10.1155/2013/309816 Text en Copyright © 2013 Ruchika K. Jain et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Jain, Ruchika K.
Nayak, Amit R.
Husain, Aliabbas A.
Panchbhai, Milind S.
Chandak, Nitin
Purohit, Hemant J.
Taori, Girdhar M.
Daginawala, Hatim F.
Kashyap, Rajpal S.
Mycobacterial Dormancy Regulon Protein Rv2623 as a Novel Biomarker for the Diagnosis of Latent and Active Tuberculous Meningitis
title Mycobacterial Dormancy Regulon Protein Rv2623 as a Novel Biomarker for the Diagnosis of Latent and Active Tuberculous Meningitis
title_full Mycobacterial Dormancy Regulon Protein Rv2623 as a Novel Biomarker for the Diagnosis of Latent and Active Tuberculous Meningitis
title_fullStr Mycobacterial Dormancy Regulon Protein Rv2623 as a Novel Biomarker for the Diagnosis of Latent and Active Tuberculous Meningitis
title_full_unstemmed Mycobacterial Dormancy Regulon Protein Rv2623 as a Novel Biomarker for the Diagnosis of Latent and Active Tuberculous Meningitis
title_short Mycobacterial Dormancy Regulon Protein Rv2623 as a Novel Biomarker for the Diagnosis of Latent and Active Tuberculous Meningitis
title_sort mycobacterial dormancy regulon protein rv2623 as a novel biomarker for the diagnosis of latent and active tuberculous meningitis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787564/
https://www.ncbi.nlm.nih.gov/pubmed/24167379
http://dx.doi.org/10.1155/2013/309816
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