Corneal Mineralization in Wistar Hannover Rats

We have recently started using Wistar Hannover rats in Japan and are now collecting background data. We have been frequently observing corneal mineralization in Wistar Hannover rats of both the RccHan(TM):WIST and Crl:WI (Han) strains. In this study, details of corneal mineralization in Wistar Hanno...

Descripción completa

Detalles Bibliográficos
Autores principales: Hashimoto, Satomi, Doi, Takuya, Wako, Yumi, Sato, Junko, Wada, Sou, Tsuchitani, Minoru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Society of Toxicologic Pathology 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787605/
https://www.ncbi.nlm.nih.gov/pubmed/24155560
http://dx.doi.org/10.1293/tox.26.275
_version_ 1782286201434144768
author Hashimoto, Satomi
Doi, Takuya
Wako, Yumi
Sato, Junko
Wada, Sou
Tsuchitani, Minoru
author_facet Hashimoto, Satomi
Doi, Takuya
Wako, Yumi
Sato, Junko
Wada, Sou
Tsuchitani, Minoru
author_sort Hashimoto, Satomi
collection PubMed
description We have recently started using Wistar Hannover rats in Japan and are now collecting background data. We have been frequently observing corneal mineralization in Wistar Hannover rats of both the RccHan(TM):WIST and Crl:WI (Han) strains. In this study, details of corneal mineralization in Wistar Hannover rats were histopathologically and ultrastructurally investigated. According to the results, Wistar Hannover rats had a much higher incidence of corneal mineralization compared with Sprague-Dawley rats. The incidence of corneal mineralization was higher in males than females. According to the histological examination, mineral deposits were positive for calcium by von Kossa’s method. Furthermore, in response to mineralization, keratocytes probably become active to play an important role against the mineralized substance.
format Online
Article
Text
id pubmed-3787605
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Japanese Society of Toxicologic Pathology
record_format MEDLINE/PubMed
spelling pubmed-37876052013-10-23 Corneal Mineralization in Wistar Hannover Rats Hashimoto, Satomi Doi, Takuya Wako, Yumi Sato, Junko Wada, Sou Tsuchitani, Minoru J Toxicol Pathol Original Article We have recently started using Wistar Hannover rats in Japan and are now collecting background data. We have been frequently observing corneal mineralization in Wistar Hannover rats of both the RccHan(TM):WIST and Crl:WI (Han) strains. In this study, details of corneal mineralization in Wistar Hannover rats were histopathologically and ultrastructurally investigated. According to the results, Wistar Hannover rats had a much higher incidence of corneal mineralization compared with Sprague-Dawley rats. The incidence of corneal mineralization was higher in males than females. According to the histological examination, mineral deposits were positive for calcium by von Kossa’s method. Furthermore, in response to mineralization, keratocytes probably become active to play an important role against the mineralized substance. Japanese Society of Toxicologic Pathology 2013-10-15 2013-09 /pmc/articles/PMC3787605/ /pubmed/24155560 http://dx.doi.org/10.1293/tox.26.275 Text en ©2013 The Japanese Society of Toxicologic Pathology http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License.
spellingShingle Original Article
Hashimoto, Satomi
Doi, Takuya
Wako, Yumi
Sato, Junko
Wada, Sou
Tsuchitani, Minoru
Corneal Mineralization in Wistar Hannover Rats
title Corneal Mineralization in Wistar Hannover Rats
title_full Corneal Mineralization in Wistar Hannover Rats
title_fullStr Corneal Mineralization in Wistar Hannover Rats
title_full_unstemmed Corneal Mineralization in Wistar Hannover Rats
title_short Corneal Mineralization in Wistar Hannover Rats
title_sort corneal mineralization in wistar hannover rats
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787605/
https://www.ncbi.nlm.nih.gov/pubmed/24155560
http://dx.doi.org/10.1293/tox.26.275
work_keys_str_mv AT hashimotosatomi cornealmineralizationinwistarhannoverrats
AT doitakuya cornealmineralizationinwistarhannoverrats
AT wakoyumi cornealmineralizationinwistarhannoverrats
AT satojunko cornealmineralizationinwistarhannoverrats
AT wadasou cornealmineralizationinwistarhannoverrats
AT tsuchitaniminoru cornealmineralizationinwistarhannoverrats

Ejemplares similares