Cargando…
Spontaneous Malignant T Cell Lymphoma in a Young Male Common Marmoset (Callithrix jacchus)
We histopathologically and immunohistochemically investigated a case of malignant lymphoma that spontaneously developed in a male common marmoset at two years of age. Beginning at two years four months of age, the animal had an enlargement of the submandibular and inguinal lymph nodes, small subcuta...
Autores principales: | , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Japanese Society of Toxicologic Pathology
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787608/ https://www.ncbi.nlm.nih.gov/pubmed/24155563 http://dx.doi.org/10.1293/tox.26.301 |
_version_ | 1782286202147176448 |
---|---|
author | Yamaguchi, Itaru Myojo, Kensuke Sanada, Hiroko Sudo, Eri Ootsuka, Sayaka Okumura, Hiroshi Takami, Atsuko Yoneshige, Tomomi Suzuki, Yui Imaizumi, Minami Takada, Chie Kimoto, Naoya Saeki, Koji Takaba, Katsumi |
author_facet | Yamaguchi, Itaru Myojo, Kensuke Sanada, Hiroko Sudo, Eri Ootsuka, Sayaka Okumura, Hiroshi Takami, Atsuko Yoneshige, Tomomi Suzuki, Yui Imaizumi, Minami Takada, Chie Kimoto, Naoya Saeki, Koji Takaba, Katsumi |
author_sort | Yamaguchi, Itaru |
collection | PubMed |
description | We histopathologically and immunohistochemically investigated a case of malignant lymphoma that spontaneously developed in a male common marmoset at two years of age. Beginning at two years four months of age, the animal had an enlargement of the submandibular and inguinal lymph nodes, small subcutaneous nodules near the right breast and an approximately fivefold increase in peripheral lymphocyte count compared with the previous examination value. The postmortem findings at two years eight months of age showed lymphadenopathy with enlargement of the thymus and spleen. Small- to intermediate-sized neoplastic lymphocytes had diffusely proliferated in the enlarged nodes. The neoplastic cells were pleomorphic and had irregularly shaped nuclei. The nuclear chromatin staining revealed hyperchromatism in the small-sized cells, and the intermediate-sized cells exhibited vesicular staining. An immunohistochemical examination indicated that the neoplastic lymphocytes were positive for CD3 and negative for CD20, thus suggesting that they had originated from T cells. In addition, the proliferation of high endothelial venules and reactive epithelioid histiocytes was observed. Scattered tingible body-laden macrophages were infrequently detected. Neoplastic lymphocytes were also observed in the thymus, spleen, heart, lungs, liver, kidneys, adrenal glands and femoral and sternal bone marrow. This malignant lymphoma in a young male common marmoset was considered to fit the category of “peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS)” according to the new WHO system of classification. |
format | Online Article Text |
id | pubmed-3787608 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Japanese Society of Toxicologic Pathology |
record_format | MEDLINE/PubMed |
spelling | pubmed-37876082013-10-23 Spontaneous Malignant T Cell Lymphoma in a Young Male Common Marmoset (Callithrix jacchus) Yamaguchi, Itaru Myojo, Kensuke Sanada, Hiroko Sudo, Eri Ootsuka, Sayaka Okumura, Hiroshi Takami, Atsuko Yoneshige, Tomomi Suzuki, Yui Imaizumi, Minami Takada, Chie Kimoto, Naoya Saeki, Koji Takaba, Katsumi J Toxicol Pathol Case Report We histopathologically and immunohistochemically investigated a case of malignant lymphoma that spontaneously developed in a male common marmoset at two years of age. Beginning at two years four months of age, the animal had an enlargement of the submandibular and inguinal lymph nodes, small subcutaneous nodules near the right breast and an approximately fivefold increase in peripheral lymphocyte count compared with the previous examination value. The postmortem findings at two years eight months of age showed lymphadenopathy with enlargement of the thymus and spleen. Small- to intermediate-sized neoplastic lymphocytes had diffusely proliferated in the enlarged nodes. The neoplastic cells were pleomorphic and had irregularly shaped nuclei. The nuclear chromatin staining revealed hyperchromatism in the small-sized cells, and the intermediate-sized cells exhibited vesicular staining. An immunohistochemical examination indicated that the neoplastic lymphocytes were positive for CD3 and negative for CD20, thus suggesting that they had originated from T cells. In addition, the proliferation of high endothelial venules and reactive epithelioid histiocytes was observed. Scattered tingible body-laden macrophages were infrequently detected. Neoplastic lymphocytes were also observed in the thymus, spleen, heart, lungs, liver, kidneys, adrenal glands and femoral and sternal bone marrow. This malignant lymphoma in a young male common marmoset was considered to fit the category of “peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS)” according to the new WHO system of classification. Japanese Society of Toxicologic Pathology 2013-10-15 2013-09 /pmc/articles/PMC3787608/ /pubmed/24155563 http://dx.doi.org/10.1293/tox.26.301 Text en ©2013 The Japanese Society of Toxicologic Pathology http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. |
spellingShingle | Case Report Yamaguchi, Itaru Myojo, Kensuke Sanada, Hiroko Sudo, Eri Ootsuka, Sayaka Okumura, Hiroshi Takami, Atsuko Yoneshige, Tomomi Suzuki, Yui Imaizumi, Minami Takada, Chie Kimoto, Naoya Saeki, Koji Takaba, Katsumi Spontaneous Malignant T Cell Lymphoma in a Young Male Common Marmoset (Callithrix jacchus) |
title | Spontaneous Malignant T Cell Lymphoma in a Young Male Common Marmoset
(Callithrix jacchus) |
title_full | Spontaneous Malignant T Cell Lymphoma in a Young Male Common Marmoset
(Callithrix jacchus) |
title_fullStr | Spontaneous Malignant T Cell Lymphoma in a Young Male Common Marmoset
(Callithrix jacchus) |
title_full_unstemmed | Spontaneous Malignant T Cell Lymphoma in a Young Male Common Marmoset
(Callithrix jacchus) |
title_short | Spontaneous Malignant T Cell Lymphoma in a Young Male Common Marmoset
(Callithrix jacchus) |
title_sort | spontaneous malignant t cell lymphoma in a young male common marmoset
(callithrix jacchus) |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787608/ https://www.ncbi.nlm.nih.gov/pubmed/24155563 http://dx.doi.org/10.1293/tox.26.301 |
work_keys_str_mv | AT yamaguchiitaru spontaneousmalignanttcelllymphomainayoungmalecommonmarmosetcallithrixjacchus AT myojokensuke spontaneousmalignanttcelllymphomainayoungmalecommonmarmosetcallithrixjacchus AT sanadahiroko spontaneousmalignanttcelllymphomainayoungmalecommonmarmosetcallithrixjacchus AT sudoeri spontaneousmalignanttcelllymphomainayoungmalecommonmarmosetcallithrixjacchus AT ootsukasayaka spontaneousmalignanttcelllymphomainayoungmalecommonmarmosetcallithrixjacchus AT okumurahiroshi spontaneousmalignanttcelllymphomainayoungmalecommonmarmosetcallithrixjacchus AT takamiatsuko spontaneousmalignanttcelllymphomainayoungmalecommonmarmosetcallithrixjacchus AT yoneshigetomomi spontaneousmalignanttcelllymphomainayoungmalecommonmarmosetcallithrixjacchus AT suzukiyui spontaneousmalignanttcelllymphomainayoungmalecommonmarmosetcallithrixjacchus AT imaizumiminami spontaneousmalignanttcelllymphomainayoungmalecommonmarmosetcallithrixjacchus AT takadachie spontaneousmalignanttcelllymphomainayoungmalecommonmarmosetcallithrixjacchus AT kimotonaoya spontaneousmalignanttcelllymphomainayoungmalecommonmarmosetcallithrixjacchus AT saekikoji spontaneousmalignanttcelllymphomainayoungmalecommonmarmosetcallithrixjacchus AT takabakatsumi spontaneousmalignanttcelllymphomainayoungmalecommonmarmosetcallithrixjacchus |