Cargando…
The Role of IL-33 in Rheumatic Diseases
Interleukin-33 (IL-33), a novel member of IL-1 family, has been recently implicated in several inflammatory and autoimmune diseases. IL-33 can be produced by various types of tissues and cells and induce gene expression of Th2-associated cytokines via binding to the orphan receptor ST2. By promoting...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787644/ https://www.ncbi.nlm.nih.gov/pubmed/24151520 http://dx.doi.org/10.1155/2013/924363 |
_version_ | 1782286211945070592 |
---|---|
author | Duan, Lihua Chen, Jie Gong, Feili Shi, Guixiu |
author_facet | Duan, Lihua Chen, Jie Gong, Feili Shi, Guixiu |
author_sort | Duan, Lihua |
collection | PubMed |
description | Interleukin-33 (IL-33), a novel member of IL-1 family, has been recently implicated in several inflammatory and autoimmune diseases. IL-33 can be produced by various types of tissues and cells and induce gene expression of Th2-associated cytokines via binding to the orphan receptor ST2. By promoting Th2 type immune response, IL-33 plays important roles in the allergy, whereas its function in autoimmune diseases attracts more attention. Recent studies reported the correlation of IL-33 with rheumatic diseases, and most of them found that the IL-33 expression levels were consistent with disease activity and development. Furthermore, evidence has indicated that IL-33-related treatment may ameliorate the pathogenic conditions and attenuate disease progression of those rheumatic diseases. Therefore, elucidation of the roles of IL-33 in rheumatic diseases would be beneficial to understand the pathogenesis and therapy of these diseases. In this paper, we will summarize the roles of IL-33 in the rheumatic diseases. |
format | Online Article Text |
id | pubmed-3787644 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-37876442013-10-22 The Role of IL-33 in Rheumatic Diseases Duan, Lihua Chen, Jie Gong, Feili Shi, Guixiu Clin Dev Immunol Review Article Interleukin-33 (IL-33), a novel member of IL-1 family, has been recently implicated in several inflammatory and autoimmune diseases. IL-33 can be produced by various types of tissues and cells and induce gene expression of Th2-associated cytokines via binding to the orphan receptor ST2. By promoting Th2 type immune response, IL-33 plays important roles in the allergy, whereas its function in autoimmune diseases attracts more attention. Recent studies reported the correlation of IL-33 with rheumatic diseases, and most of them found that the IL-33 expression levels were consistent with disease activity and development. Furthermore, evidence has indicated that IL-33-related treatment may ameliorate the pathogenic conditions and attenuate disease progression of those rheumatic diseases. Therefore, elucidation of the roles of IL-33 in rheumatic diseases would be beneficial to understand the pathogenesis and therapy of these diseases. In this paper, we will summarize the roles of IL-33 in the rheumatic diseases. Hindawi Publishing Corporation 2013 2013-09-15 /pmc/articles/PMC3787644/ /pubmed/24151520 http://dx.doi.org/10.1155/2013/924363 Text en Copyright © 2013 Lihua Duan et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Duan, Lihua Chen, Jie Gong, Feili Shi, Guixiu The Role of IL-33 in Rheumatic Diseases |
title | The Role of IL-33 in Rheumatic Diseases |
title_full | The Role of IL-33 in Rheumatic Diseases |
title_fullStr | The Role of IL-33 in Rheumatic Diseases |
title_full_unstemmed | The Role of IL-33 in Rheumatic Diseases |
title_short | The Role of IL-33 in Rheumatic Diseases |
title_sort | role of il-33 in rheumatic diseases |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787644/ https://www.ncbi.nlm.nih.gov/pubmed/24151520 http://dx.doi.org/10.1155/2013/924363 |
work_keys_str_mv | AT duanlihua theroleofil33inrheumaticdiseases AT chenjie theroleofil33inrheumaticdiseases AT gongfeili theroleofil33inrheumaticdiseases AT shiguixiu theroleofil33inrheumaticdiseases AT duanlihua roleofil33inrheumaticdiseases AT chenjie roleofil33inrheumaticdiseases AT gongfeili roleofil33inrheumaticdiseases AT shiguixiu roleofil33inrheumaticdiseases |