Orai3 TM3 point mutation G158C alters kinetics of 2-APB–induced gating by disulfide bridge formation with TM2 C101

After endoplasmic reticulum (ER) Ca(2+) store depletion, Orai channels in the plasma membrane (PM) are activated directly by ER-resident STIM proteins to form the Ca(2+)-selective Ca(2+) release–activated Ca(2+) (CRAC) channel. However, in the absence of Ca(2+) store depletion and STIM interaction,...

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Detalles Bibliográficos
Autores principales: Amcheslavsky, Anna, Safrina, Olga, Cahalan, Michael D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787773/
https://www.ncbi.nlm.nih.gov/pubmed/24081982
http://dx.doi.org/10.1085/jgp.201311030

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787773/
https://www.ncbi.nlm.nih.gov/pubmed/24081982
http://dx.doi.org/10.1085/jgp.201311030

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