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Direct interaction of eag domains and cyclic nucleotide–binding homology domains regulate deactivation gating in hERG channels

Human ether-á-go-go (eag)-related gene (hERG) potassium channels play a critical role in cardiac repolarization and are characterized by unusually slow closing (deactivation) kinetics. The N-terminal “eag” domain and a C-terminal C-linker/cyclic nucleotide–binding homology domain (CNBHD) are require...

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Detalles Bibliográficos
Autores principales:	Gianulis, Elena C., Liu, Qiangni, Trudeau, Matthew C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2013
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787778/ https://www.ncbi.nlm.nih.gov/pubmed/24043860 http://dx.doi.org/10.1085/jgp.201310995

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