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Creatine Kinase-Overexpression Improves Myocardial Energetics, Contractile Dysfunction and Survival in Murine Doxorubicin Cardiotoxicity

Doxorubicin (DOX) is a commonly used life-saving antineoplastic agent that also causes dose-dependent cardiotoxicity. Because ATP is absolutely required to sustain normal cardiac contractile function and because impaired ATP synthesis through creatine kinase (CK), the primary myocardial energy reser...

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Detalles Bibliográficos
Autores principales:	Gupta, Ashish, Rohlfsen, Cory, Leppo, Michelle K., Chacko, Vadappuram P., Wang, Yibin, Steenbergen, Charles, Weiss, Robert G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3788056/ https://www.ncbi.nlm.nih.gov/pubmed/24098344 http://dx.doi.org/10.1371/journal.pone.0074675

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