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Suppression of Alzheimer’s Disease-Related Phenotypes by Geranylgeranylacetone in Mice

Amyloid-β peptide (Aβ) plays an important role in the pathogenesis of Alzheimer’s disease (AD). Aβ is generated by the secretase-mediated proteolysis of β-amyloid precursor protein (APP), and cleared by enzyme-mediated degradation and phagocytosis. Transforming growth factor (TGF)-β1 stimulates this...

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Detalles Bibliográficos
Autores principales:	Hoshino, Tatsuya, Suzuki, Koichiro, Matsushima, Takahide, Yamakawa, Naoki, Suzuki, Toshiharu, Mizushima, Tohru
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3788141/ https://www.ncbi.nlm.nih.gov/pubmed/24098472 http://dx.doi.org/10.1371/journal.pone.0076306

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