Mesenchymal Stem/Stromal Cells: A New "Cells as Drugs" Paradigm. Efficacy and Critical Aspects in Cell Therapy

Mesenchymal stem cells (MSCs) were first isolated more than 50 years ago from the bone marrow. Currently MSCs may also be isolated from several alternative sources and they have been used in more than a hundred clinical trials worldwide to treat a wide variety of diseases. The MSCs mechanism of acti...

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Detalles Bibliográficos
Autores principales: de Girolamo, Laura, Lucarelli, Enrico, Alessandri, Giulio, Avanzini, Maria Antonietta, Bernardo, Maria Ester, Biagi, Ettore, Brini, Anna Teresa, D’Amico, Giovanna, Fagioli, Franca, Ferrero, Ivana, Locatelli, Franco, Maccario, Rita, Marazzi, Mario, Parolini, Ornella, Pessina, Augusto, Torre, Maria Luisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3788322/
https://www.ncbi.nlm.nih.gov/pubmed/23278600
http://dx.doi.org/10.2174/1381612811319130015
Descripción
Sumario:Mesenchymal stem cells (MSCs) were first isolated more than 50 years ago from the bone marrow. Currently MSCs may also be isolated from several alternative sources and they have been used in more than a hundred clinical trials worldwide to treat a wide variety of diseases. The MSCs mechanism of action is undefined and currently under investigation. For in vivo purposes MSCs must be produced in compliance with good manufacturing practices and this has stimulated research on MSCs characterization and safety. The objective of this review is to describe recent developments regarding MSCs properties, physiological effects, delivery, clinical applications and possible side effects.

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