Mesenchymal Stem/Stromal Cells: A New "Cells as Drugs" Paradigm. Efficacy and Critical Aspects in Cell Therapy

Mesenchymal stem cells (MSCs) were first isolated more than 50 years ago from the bone marrow. Currently MSCs may also be isolated from several alternative sources and they have been used in more than a hundred clinical trials worldwide to treat a wide variety of diseases. The MSCs mechanism of acti...

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Autores principales: de Girolamo, Laura, Lucarelli, Enrico, Alessandri, Giulio, Avanzini, Maria Antonietta, Bernardo, Maria Ester, Biagi, Ettore, Brini, Anna Teresa, D’Amico, Giovanna, Fagioli, Franca, Ferrero, Ivana, Locatelli, Franco, Maccario, Rita, Marazzi, Mario, Parolini, Ornella, Pessina, Augusto, Torre, Maria Luisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3788322/
https://www.ncbi.nlm.nih.gov/pubmed/23278600
http://dx.doi.org/10.2174/1381612811319130015
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author de Girolamo, Laura
Lucarelli, Enrico
Alessandri, Giulio
Avanzini, Maria Antonietta
Bernardo, Maria Ester
Biagi, Ettore
Brini, Anna Teresa
D’Amico, Giovanna
Fagioli, Franca
Ferrero, Ivana
Locatelli, Franco
Maccario, Rita
Marazzi, Mario
Parolini, Ornella
Pessina, Augusto
Torre, Maria Luisa
author_facet de Girolamo, Laura
Lucarelli, Enrico
Alessandri, Giulio
Avanzini, Maria Antonietta
Bernardo, Maria Ester
Biagi, Ettore
Brini, Anna Teresa
D’Amico, Giovanna
Fagioli, Franca
Ferrero, Ivana
Locatelli, Franco
Maccario, Rita
Marazzi, Mario
Parolini, Ornella
Pessina, Augusto
Torre, Maria Luisa
author_sort de Girolamo, Laura
collection PubMed
description Mesenchymal stem cells (MSCs) were first isolated more than 50 years ago from the bone marrow. Currently MSCs may also be isolated from several alternative sources and they have been used in more than a hundred clinical trials worldwide to treat a wide variety of diseases. The MSCs mechanism of action is undefined and currently under investigation. For in vivo purposes MSCs must be produced in compliance with good manufacturing practices and this has stimulated research on MSCs characterization and safety. The objective of this review is to describe recent developments regarding MSCs properties, physiological effects, delivery, clinical applications and possible side effects.
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spelling pubmed-37883222013-10-03 Mesenchymal Stem/Stromal Cells: A New "Cells as Drugs" Paradigm. Efficacy and Critical Aspects in Cell Therapy de Girolamo, Laura Lucarelli, Enrico Alessandri, Giulio Avanzini, Maria Antonietta Bernardo, Maria Ester Biagi, Ettore Brini, Anna Teresa D’Amico, Giovanna Fagioli, Franca Ferrero, Ivana Locatelli, Franco Maccario, Rita Marazzi, Mario Parolini, Ornella Pessina, Augusto Torre, Maria Luisa Curr Pharm Des Article Mesenchymal stem cells (MSCs) were first isolated more than 50 years ago from the bone marrow. Currently MSCs may also be isolated from several alternative sources and they have been used in more than a hundred clinical trials worldwide to treat a wide variety of diseases. The MSCs mechanism of action is undefined and currently under investigation. For in vivo purposes MSCs must be produced in compliance with good manufacturing practices and this has stimulated research on MSCs characterization and safety. The objective of this review is to describe recent developments regarding MSCs properties, physiological effects, delivery, clinical applications and possible side effects. Bentham Science Publishers 2013-04 2013-04 /pmc/articles/PMC3788322/ /pubmed/23278600 http://dx.doi.org/10.2174/1381612811319130015 Text en © 2013 Bentham Science Publishers http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
de Girolamo, Laura
Lucarelli, Enrico
Alessandri, Giulio
Avanzini, Maria Antonietta
Bernardo, Maria Ester
Biagi, Ettore
Brini, Anna Teresa
D’Amico, Giovanna
Fagioli, Franca
Ferrero, Ivana
Locatelli, Franco
Maccario, Rita
Marazzi, Mario
Parolini, Ornella
Pessina, Augusto
Torre, Maria Luisa
Mesenchymal Stem/Stromal Cells: A New "Cells as Drugs" Paradigm. Efficacy and Critical Aspects in Cell Therapy
title Mesenchymal Stem/Stromal Cells: A New "Cells as Drugs" Paradigm. Efficacy and Critical Aspects in Cell Therapy
title_full Mesenchymal Stem/Stromal Cells: A New "Cells as Drugs" Paradigm. Efficacy and Critical Aspects in Cell Therapy
title_fullStr Mesenchymal Stem/Stromal Cells: A New "Cells as Drugs" Paradigm. Efficacy and Critical Aspects in Cell Therapy
title_full_unstemmed Mesenchymal Stem/Stromal Cells: A New "Cells as Drugs" Paradigm. Efficacy and Critical Aspects in Cell Therapy
title_short Mesenchymal Stem/Stromal Cells: A New "Cells as Drugs" Paradigm. Efficacy and Critical Aspects in Cell Therapy
title_sort mesenchymal stem/stromal cells: a new "cells as drugs" paradigm. efficacy and critical aspects in cell therapy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3788322/
https://www.ncbi.nlm.nih.gov/pubmed/23278600
http://dx.doi.org/10.2174/1381612811319130015
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