Brain-derived neurotrophic factor in VMH as the causal factor for and therapeutic tool to treat visceral adiposity and hyperleptinemia in type 2 diabetic Goto–Kakizaki rats

We previously reported that the type 2 diabetic Goto–Kakizaki (GK) rats at young adult ages (6–12 weeks) exhibited increased visceral fat mass and hyperleptinemia, due to hyperphagia caused primarily by neuropeptide Y (NPY) overexpression in the hypothalamic arcuate nucleus. Later, we found that GK...

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Detalles Bibliográficos
Autores principales: Maekawa, Fumihiko, Fujiwara, Ken, Toriya, Masako, Maejima, Yuko, Nishio, Takashi, Toyoda, Yukiyasu, Nohara, Keiko, Yashiro, Takashi, Yada, Toshihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3788348/
https://www.ncbi.nlm.nih.gov/pubmed/24106476
http://dx.doi.org/10.3389/fnsyn.2013.00007

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