Oncogenic B-RAF(V600E) signaling induces the T-box3 transcriptional repressor to repress E-cadherin and enhance melanoma cell invasion

Approximately 50% of melanomas require oncogenic B-RAF(V600E) signaling for proliferation, survival and metastasis, and the use of highly selective B-RAF inhibitors has yielded remarkable, albeit short term, clinical responses. Re-activation of signaling downstream of B-RAF is frequently associated...

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Detalles Bibliográficos
Autores principales: Boyd, Suzanah C., Mijatov, Branka, Pupo, Gulietta M., Tran, Sieu L., Gowrishankar, Kavitha, Shaw, Heather M., Goding, Colin R., Scolyer, Richard A., Mann, Graham J., Kefford, Richard F., Rizos, Helen, Becker, Therese M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3788590/
https://www.ncbi.nlm.nih.gov/pubmed/23190890
http://dx.doi.org/10.1038/jid.2012.421

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3788590/
https://www.ncbi.nlm.nih.gov/pubmed/23190890
http://dx.doi.org/10.1038/jid.2012.421

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