CYLD Deubiquitinates RIP1 in the TNFα-Induced Necrosome to Facilitate Kinase Activation and Programmed Necrosis

BACKGROUND: Necroptosis/programmed necrosis is initiated by a macro-molecular protein complex termed the necrosome. Receptor interacting protein kinase 1 (RIPK1/RIP1) and RIP3 are key components of the necrosome. TNFα is a prototypic inducer of necrosome activation, and it is widely believed that de...

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Detalles Bibliográficos
Autores principales: Moquin, David M., McQuade, Thomas, Chan, Francis Ka-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3788787/
https://www.ncbi.nlm.nih.gov/pubmed/24098568
http://dx.doi.org/10.1371/journal.pone.0076841

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3788787/
https://www.ncbi.nlm.nih.gov/pubmed/24098568
http://dx.doi.org/10.1371/journal.pone.0076841

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