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A distinct histopathological variant of a malignant melanoma with perivascular pseudorosettes: A case report

Although a rare condition, rosette formation in malignant melanoma has been previously documented. The present study describes the second documented case of malignant melanoma with perivascular pseudorosettes. A 38-year-old male presented with a black nodule on his back. Histopathological study reve...

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Autores principales: ISHIDA, MITSUAKI, IWAI, MUNEO, YOSHIDA, KEIKO, KAGOTANI, AKIKO, OKABE, HIDETOSHI
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789052/
https://www.ncbi.nlm.nih.gov/pubmed/24137388
http://dx.doi.org/10.3892/ol.2013.1430
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author ISHIDA, MITSUAKI
IWAI, MUNEO
YOSHIDA, KEIKO
KAGOTANI, AKIKO
OKABE, HIDETOSHI
author_facet ISHIDA, MITSUAKI
IWAI, MUNEO
YOSHIDA, KEIKO
KAGOTANI, AKIKO
OKABE, HIDETOSHI
author_sort ISHIDA, MITSUAKI
collection PubMed
description Although a rare condition, rosette formation in malignant melanoma has been previously documented. The present study describes the second documented case of malignant melanoma with perivascular pseudorosettes. A 38-year-old male presented with a black nodule on his back. Histopathological study revealed diffuse proliferation of neoplastic cells in the dermis and subcutis. A section of the tumor (~30%) was composed of a conventional malignant melanoma component. The remaining area was comprised of medium-sized polygonal cells with slightly eosinophilic cytoplasm and small-to-medium, round nuclei. Melanin pigment was rarely observed. A noteworthy observation was the presence of perivascular pseudorosette formations, which were characterized by their radial arrangement around the blood vessels, with a perivascular, anuclear zone. Immunohistochemically, the neoplastic cells were diffusely positive for S-100 protein and Melan-A and focally positive for HMB-45. Clinicopathological analyses of cases of malignant melanoma with rosette formations revealed that the types of rosette included the Homer-Wright type (two cases), perivascular pseudorosettes (two cases) and an unclassifiable type (one case). Immunohistochemical analysis is a useful method for forming a diagnosis as Melan-A or HMB-45 are generally expressed in all cases. Rosette formation in malignant melanoma is a distinct histopathological variant and may be an under-recognized phenomenon. Therefore, its recognition is significant for obtaining an accurate diagnosis of malignant melanoma.
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spelling pubmed-37890522013-10-17 A distinct histopathological variant of a malignant melanoma with perivascular pseudorosettes: A case report ISHIDA, MITSUAKI IWAI, MUNEO YOSHIDA, KEIKO KAGOTANI, AKIKO OKABE, HIDETOSHI Oncol Lett Articles Although a rare condition, rosette formation in malignant melanoma has been previously documented. The present study describes the second documented case of malignant melanoma with perivascular pseudorosettes. A 38-year-old male presented with a black nodule on his back. Histopathological study revealed diffuse proliferation of neoplastic cells in the dermis and subcutis. A section of the tumor (~30%) was composed of a conventional malignant melanoma component. The remaining area was comprised of medium-sized polygonal cells with slightly eosinophilic cytoplasm and small-to-medium, round nuclei. Melanin pigment was rarely observed. A noteworthy observation was the presence of perivascular pseudorosette formations, which were characterized by their radial arrangement around the blood vessels, with a perivascular, anuclear zone. Immunohistochemically, the neoplastic cells were diffusely positive for S-100 protein and Melan-A and focally positive for HMB-45. Clinicopathological analyses of cases of malignant melanoma with rosette formations revealed that the types of rosette included the Homer-Wright type (two cases), perivascular pseudorosettes (two cases) and an unclassifiable type (one case). Immunohistochemical analysis is a useful method for forming a diagnosis as Melan-A or HMB-45 are generally expressed in all cases. Rosette formation in malignant melanoma is a distinct histopathological variant and may be an under-recognized phenomenon. Therefore, its recognition is significant for obtaining an accurate diagnosis of malignant melanoma. D.A. Spandidos 2013-09 2013-06-28 /pmc/articles/PMC3789052/ /pubmed/24137388 http://dx.doi.org/10.3892/ol.2013.1430 Text en Copyright © 2013, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Articles
ISHIDA, MITSUAKI
IWAI, MUNEO
YOSHIDA, KEIKO
KAGOTANI, AKIKO
OKABE, HIDETOSHI
A distinct histopathological variant of a malignant melanoma with perivascular pseudorosettes: A case report
title A distinct histopathological variant of a malignant melanoma with perivascular pseudorosettes: A case report
title_full A distinct histopathological variant of a malignant melanoma with perivascular pseudorosettes: A case report
title_fullStr A distinct histopathological variant of a malignant melanoma with perivascular pseudorosettes: A case report
title_full_unstemmed A distinct histopathological variant of a malignant melanoma with perivascular pseudorosettes: A case report
title_short A distinct histopathological variant of a malignant melanoma with perivascular pseudorosettes: A case report
title_sort distinct histopathological variant of a malignant melanoma with perivascular pseudorosettes: a case report
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789052/
https://www.ncbi.nlm.nih.gov/pubmed/24137388
http://dx.doi.org/10.3892/ol.2013.1430
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