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Expression and clinical significance of cyclin kinase subunit 2 in colorectal cancer
The overexpression of cyclin kinase subunit 2 (CKS2) is tightly correlated with tumor aggressiveness and prognosis in various malignancies, including gastric, breast, liver and prostate cancer. However, whether CKS2 is upregulated in colorectal cancer (CRC) remains unknown. The aim of the present st...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789069/ https://www.ncbi.nlm.nih.gov/pubmed/24137409 http://dx.doi.org/10.3892/ol.2013.1456 |
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author | YU, MINHAO ZHONG, MING QIAO, ZHONGDONG |
author_facet | YU, MINHAO ZHONG, MING QIAO, ZHONGDONG |
author_sort | YU, MINHAO |
collection | PubMed |
description | The overexpression of cyclin kinase subunit 2 (CKS2) is tightly correlated with tumor aggressiveness and prognosis in various malignancies, including gastric, breast, liver and prostate cancer. However, whether CKS2 is upregulated in colorectal cancer (CRC) remains unknown. The aim of the present study was to analyze CKS2 expression levels in CRC, and to determine the clinical diagnostic and prognostic values of CKS2 overexpression in CRC patients. CKS2 expression was analyzed at the mRNA and protein levels by quantitative (q)PCR and western blot analysis. CKS2 expression was significantly upregulated in CRC compared with the adjacent non-cancer and normal colorectal tissues. The overexpression of CKS2 was correlated with poor differentiation and the pathological stage. In addition, CKS2 overexpression was correlated with aggressive tumor progression in CRC, which indicated that CKS2 may serve as a good CRC biomarker. |
format | Online Article Text |
id | pubmed-3789069 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-37890692013-10-17 Expression and clinical significance of cyclin kinase subunit 2 in colorectal cancer YU, MINHAO ZHONG, MING QIAO, ZHONGDONG Oncol Lett Articles The overexpression of cyclin kinase subunit 2 (CKS2) is tightly correlated with tumor aggressiveness and prognosis in various malignancies, including gastric, breast, liver and prostate cancer. However, whether CKS2 is upregulated in colorectal cancer (CRC) remains unknown. The aim of the present study was to analyze CKS2 expression levels in CRC, and to determine the clinical diagnostic and prognostic values of CKS2 overexpression in CRC patients. CKS2 expression was analyzed at the mRNA and protein levels by quantitative (q)PCR and western blot analysis. CKS2 expression was significantly upregulated in CRC compared with the adjacent non-cancer and normal colorectal tissues. The overexpression of CKS2 was correlated with poor differentiation and the pathological stage. In addition, CKS2 overexpression was correlated with aggressive tumor progression in CRC, which indicated that CKS2 may serve as a good CRC biomarker. D.A. Spandidos 2013-09 2013-07-11 /pmc/articles/PMC3789069/ /pubmed/24137409 http://dx.doi.org/10.3892/ol.2013.1456 Text en Copyright © 2013, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Articles YU, MINHAO ZHONG, MING QIAO, ZHONGDONG Expression and clinical significance of cyclin kinase subunit 2 in colorectal cancer |
title | Expression and clinical significance of cyclin kinase subunit 2 in colorectal cancer |
title_full | Expression and clinical significance of cyclin kinase subunit 2 in colorectal cancer |
title_fullStr | Expression and clinical significance of cyclin kinase subunit 2 in colorectal cancer |
title_full_unstemmed | Expression and clinical significance of cyclin kinase subunit 2 in colorectal cancer |
title_short | Expression and clinical significance of cyclin kinase subunit 2 in colorectal cancer |
title_sort | expression and clinical significance of cyclin kinase subunit 2 in colorectal cancer |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789069/ https://www.ncbi.nlm.nih.gov/pubmed/24137409 http://dx.doi.org/10.3892/ol.2013.1456 |
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