WWOX suppresses autophagy for inducing apoptosis in methotrexate-treated human squamous cell carcinoma

Squamous cell carcinoma (SCC) cells refractory to initial chemotherapy frequently develop disease relapse and distant metastasis. We show here that tumor suppressor WW domain-containing oxidoreductase (WWOX) (also named FOR or WOX1) regulates the susceptibility of SCC to methotrexate (MTX) in vitro...

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Detalles Bibliográficos
Autores principales: Tsai, C-W, Lai, F-J, Sheu, H-M, Lin, Y-S, Chang, T-H, Jan, M-S, Chen, S-M, Hsu, P-C, Huang, T-T, Huang, T-C, Sheen, M-C, Chen, S-T, Chang, W-C, Chang, N-S, Hsu, L-J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789168/
https://www.ncbi.nlm.nih.gov/pubmed/24008736
http://dx.doi.org/10.1038/cddis.2013.308

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