A novel extracellular role for tissue transglutaminase in matrix-bound VEGF-mediated angiogenesis

The importance of tissue transglutaminase (TG2) in angiogenesis is unclear and contradictory. Here we show that inhibition of extracellular TG2 protein crosslinking or downregulation of TG2 expression leads to inhibition of angiogenesis in cell culture, the aorta ring assay and in vivo models. In a...

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Detalles Bibliográficos
Autores principales: Wang, Z, Perez, M, Caja, S, Melino, G, Johnson, T S, Lindfors, K, Griffin, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789176/
https://www.ncbi.nlm.nih.gov/pubmed/24052076
http://dx.doi.org/10.1038/cddis.2013.318

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