Activated microglia mediate synapse loss and short-term memory deficits in a mouse model of transthyretin-related oculoleptomeningeal amyloidosis

Oculoleptomeningeal amyloidosis (OA) is a fatal and untreatable hereditary disease characterized by the accumulation of transthyretin (TTR) amyloid within the central nervous system. The mechanisms underlying the pathogenesis of OA, and in particular how amyloid triggers neuronal damage, are still u...

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Detalles Bibliográficos
Autores principales: Azevedo, E P, Ledo, J H, Barbosa, G, Sobrinho, M, Diniz, L, Fonseca, A C C, Gomes, F, Romão, L, Lima, F R S, Palhano, F L, Ferreira, S T, Foguel, D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789183/
https://www.ncbi.nlm.nih.gov/pubmed/24008733
http://dx.doi.org/10.1038/cddis.2013.325

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