The HDAC inhibitor, MPT0E028, enhances erlotinib-induced cell death in EGFR-TKI-resistant NSCLC cells

Epidermal growth factor receptor (EGFR), which promotes cell survival and division, is found at abnormally high levels on the surface of many cancer cell types, including many cases of non-small cell lung cancer. Erlotinib (Tarceva), an oral small-molecule tyrosine kinase inhibitor, is a so-called t...

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Detalles Bibliográficos
Autores principales: Chen, M-C, Chen, C-H, Wang, J-C, Tsai, A-C, Liou, J-P, Pan, S-L, Teng, C-M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789188/
https://www.ncbi.nlm.nih.gov/pubmed/24052078
http://dx.doi.org/10.1038/cddis.2013.330

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