Cargando…

A novel selective small-molecule PI3K inhibitor is effective against human multiple myeloma in vitro and in vivo

Developing effective therapies against multiple myeloma (MM) is an unresolved challenge. Phosphatidylinositol-3-kinase (PI3K) activation may be associated with tumor progression and drug resistance, and inhibiting PI3K can induce apoptosis in MM cells. Thus, targeting of PI3K is predicted to increas...

Descripción completa

Detalles Bibliográficos
Autores principales:	Glauer, J, Pletz, N, Schön, M, Schneider, P, Liu, N, Ziegelbauer, K, Emmert, S, Wulf, G G, Schön, M P
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2013
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789203/ https://www.ncbi.nlm.nih.gov/pubmed/24013662 http://dx.doi.org/10.1038/bcj.2013.37

Ejemplares similares

Small molecule MIRA-1 induces in vitro and in vivo anti-myeloma activity and synergizes with current anti-myeloma agents
por: Saha, M N, et al.
Publicado: (2014)

The Identification of Potent, Selective, and Brain Penetrant PI5P4Kγ Inhibitors as In Vivo-Ready Tool Molecules
por: Rooney, Timothy P. C., et al.
Publicado: (2022)

Inhibitors of selectin functions in the treatment of inflammatory skin disorders
por: Schön, Michael P
Publicado: (2005)

Efficacy of dual PI-3K and mTOR inhibitors in vitro and in vivo in acute lymphoblastic leukemia
por: Wong, Jacky, et al.
Publicado: (2014)

The PI3Kδ Inhibitor Idelalisib Inhibits Homing in an in Vitro and in Vivo Model of B ALL
por: Adam, Etai, et al.
Publicado: (2017)

Combination of Ribociclib with BET-Bromodomain and PI3K/mTOR Inhibitors for Medulloblastoma Treatment In Vitro and In Vivo
por: Jonchere, Barbara, et al.
Publicado: (2023)

PI3Kδ and PI3Kγ isoforms have distinct functions in regulating pro-tumoural signalling in the multiple myeloma microenvironment
por: Piddock, R E, et al.
Publicado: (2017)

Tumor-Preferential Induction of Immune Responses and Epidermal Cell Death in Actinic Keratoses by Ingenol Mebutate
por: Emmert, Steffen, et al.
Publicado: (2016)

Synthesis, Molecular Docking, In Vitro and In Vivo Studies of Novel Dimorpholinoquinazoline-Based Potential Inhibitors of PI3K/Akt/mTOR Pathway
por: Zapevalova, Maria V., et al.
Publicado: (2022)

Antitumor activity of MEK and PI3K inhibitors against malignant pleural mesothelioma cells in vitro and in vivo
por: MIYOSHI, SEIGO, et al.
Publicado: (2012)

The PI3K inhibitor GDC-0941 displays promising in vitro and in vivo efficacy for targeted medulloblastoma therapy
por: Ehrhardt, Michael, et al.
Publicado: (2014)

The dual PI3K/mTOR inhibitor dactolisib elicits anti-tumor activity in vitro and in vivo
por: Shi, Fei, et al.
Publicado: (2017)

A Dual PI3K/HDAC Inhibitor Downregulates Oncogenic Pathways in Hematologic Tumors In Vitro and In Vivo
por: Yan, Zheng, et al.
Publicado: (2021)

A lurking threat: transfer of peanut allergy through peripheral blood stem cell transplantation
por: Brauns, Birka, et al.
Publicado: (2016)

Selection Study for B+- -> (K-+ pi+- pi-+ pi+-)D K+- and B+- -> (K+ K- pi+ pi-)D K+-".
por: Hunt, P, et al.
Publicado: (2009)

Closing escape routes: inhibition of IL-8 signaling enhances the anti-tumor efficacy of PI3K inhibitors
por: Juvekar, Ashish, et al.
Publicado: (2013)

Study of the K+K-pi+pi- system centrally produced in the reactions pi+p --> pi+(K+K-pi+pi-)p and pp --> p(K+K-pi+pi-)p at 85 GeV/c
por: Armstrong, T A, et al.
Publicado: (1986)

Identification of a CARM1 Inhibitor with Potent In Vitro and In Vivo Activity in Preclinical Models of Multiple Myeloma
por: Drew, Allison E., et al.
Publicado: (2017)

Identification of a promising PI3K inhibitor for the treatment of multiple myeloma through the structural optimization
por: Han, Kunkun, et al.
Publicado: (2014)

Measurement of relative branching fractions for D$^{+}$ --> K$^{-}$K$^{+}$K$^{+}$ and D$_{s}^{+}$ --> $\pi^{-}\pi^{+ }\pi^{+}$ decays
por: Adamovich, M I, et al.
Publicado: (1993)

Correction: The dual PI3K/mTOR inhibitor dactolisib elicits anti-tumor activity in vitro and in vivo
por: Shi, Fei, et al.
Publicado: (2018)

In Vitro and in Vivo Activity of mTOR Kinase and PI3K Inhibitors Against Leishmania donovani and Trypanosoma brucei
por: Phan, Trong-Nhat, et al.
Publicado: (2020)

Precision measurement of the ratio BR($K_{S} \to \pi^{+}\pi^{-}e^{+}e^{-}$)/BR($K_{L} \to \pi^{+}\pi^{-}\pi^{0}_{D}$)
por: Batley, J R, et al.
Publicado: (2010)

Measurement of the absolute branching fractions for D$^{0}$ decays into K$^{-}\pi^{+}$, K$^{-}\pi^{+}\pi^{+}\pi^{-}$, $\overline{K}^{0}\pi^{+}\pi^{-}$
por: Albrecht, H, et al.
Publicado: (1994)

Coherent production of $K^{+} \pi^{+} \pi^{-}$ on nuclei and determination of the $K^{+} \pi^{+} \pi^{-}$ - nucleon cross section
por: Bemporad, C, et al.
Publicado: (1973)

Study of the centrally produced $\pi\pi$ and $K\bar{K}$ systems
por: Armstrong, T A, et al.
Publicado: (1991)

First determination of the CP content of $D \to \pi^+ \pi^- \pi^0$ and $D \to K^+K^-\pi^0$
por: Nayak, M., et al.
Publicado: (2014)

PI3K inhibitors in thrombosis and cardiovascular disease
por: Durrant, Tom N., et al.
Publicado: (2020)

Model-independent search for $CP$ violation in $D^{0} \to K^{-}K^{+}\pi^{-}\pi^{+}$ and $D^{0} \to \pi^{-}\pi^{+}\pi^{+}\pi^{-}$ decays
por: Aaij, R, et al.
Publicado: (2013)

A partial-wave analysis of the (K$^{+}$K$^{-}$pi$^{-}$) system produced in pi$^{-}$p --> K$^{+}$K$^{-}$pi$^{-}$p at 16 GeV/c
por: Armstrong, T A, et al.
Publicado: (1981)

Production of the K $\pi \pi$ system in K+n and K+p interactions at 4.6 GeV/c
por: De Jongh, G, et al.
Publicado: (1973)

Production of the K $\pi\pi$ system in K$^{+}$+n and K$^{+}$p interactions at 4.6 GeV/c
por: De Jongh, G, et al.
Publicado: (1973)

Analysis of the reaction $K^{-}p \rightarrow K^{-}\pi^{-}\pi^{+}p$ at 40 GeV/c
por: Antipov, Yu M, et al.
Publicado: (1975)

In vitro and in vivo efficacy of the novel oral proteasome inhibitor NNU546 in multiple myeloma
por: Zhou, Hui, et al.
Publicado: (2020)

Observation of $\pi^- K^+$ and $\pi^+ K^-$ atoms
por: Adeva, B., et al.
Publicado: (2016)

Coupled channel analysis of $\pi^+ \pi^ -\pi^0$, $K^+ K^- \pi^0$ and $K^{\pm} K^0_S \pi^{\mp}$ from $\bar p p$ annihilation at rest in hydrogen targets at three densities
por: Bargiotti, M, et al.
Publicado: (2003)

Observation of the suppressed ADS modes $B^\pm \to [\pi^\pm K^\mp \pi^+\pi^-]_D K^\pm$ and $B^\pm \to [\pi^\pm K^\mp \pi^+\pi^-]_D \pi^\pm$
por: Aaij, R, et al.
Publicado: (2013)

Search for direct CP violating charge asymmetries in $K^\pm\to\pi^\pm\pi^+\pi^-$ and $K^\pm\to\pi^\pm\pi^0\pi^0$ decays
por: Batley, J.R., et al.
Publicado: (2007)

First observation of the decays $\overline{B}^0 \to D^+ K^- \pi^+ \pi^-$ and $B^- \to D^0 K^- \pi^+ \pi^-$
por: Aaij, R, et al.
Publicado: (2012)

Measurement of strange boson production in the reaction $K^{\pm}p \rightarrow K^{0}_{s}\pi^{\pm}p$ and $K^{\pm}p \rightarrow K^{\pm}\pi^{+}\pi^{-}p$ at the PS
por: Busnello, R, et al.
Publicado: (1972)

Cannot write session to /tmp/vufind_sessions/sess_i7qru9s8kc3gn8skhl3g689k5d