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Halogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant p53
[Image: see text] The destabilizing p53 cancer mutation Y220C creates a druggable surface crevice. We developed a strategy exploiting halogen bonding for lead discovery to stabilize the mutant with small molecules. We designed halogen-enriched fragment libraries (HEFLibs) as starting points to compl...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789257/ https://www.ncbi.nlm.nih.gov/pubmed/22439615 http://dx.doi.org/10.1021/ja301056a |