Constitutive stabilization of hypoxia-inducible factor alpha selectively promotes the self-renewal of mesenchymal progenitors and maintains mesenchymal stromal cells in an undifferentiated state

With the increasing use of culture-expanded mesenchymal stromal cells (MSCs) for cell therapies, factors that regulate the cellular characteristics of MSCs have been of major interest. Oxygen concentration has been shown to influence the functions of MSCs, as well as other normal and malignant stem...

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Detalles Bibliográficos
Autores principales: Park, In-Ho, Kim, Kwang-Ho, Choi, Hyun-Kyung, Shim, Jae-Seung, Whang, Soo-Young, June Hahn, Sang, Kwon, Oh-Joo, Oh, Il-Hoan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789268/
https://www.ncbi.nlm.nih.gov/pubmed/24071737
http://dx.doi.org/10.1038/emm.2013.87

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