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Epimedium Extract Promotes Peripheral Nerve Regeneration in Rats

Effects of Epimedium extract and its constituent icariin on peripheral nerve repair were investigated in a crush injury rat model. Animals were divided into four groups: sham, control, Epimedium extract, and icariin groups. At postoperative weeks 1, 2, 4, and 8, nerve regeneration and functional rec...

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Autores principales: Kou, Yuhui, Wang, Zhiyong, Wu, Zhihong, Zhang, Peixun, Zhang, Yu, Yin, Xiaofeng, Wong, Xisheng, Qiu, Guixing, Jiang, Baoguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789416/
https://www.ncbi.nlm.nih.gov/pubmed/24159356
http://dx.doi.org/10.1155/2013/954798
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author Kou, Yuhui
Wang, Zhiyong
Wu, Zhihong
Zhang, Peixun
Zhang, Yu
Yin, Xiaofeng
Wong, Xisheng
Qiu, Guixing
Jiang, Baoguo
author_facet Kou, Yuhui
Wang, Zhiyong
Wu, Zhihong
Zhang, Peixun
Zhang, Yu
Yin, Xiaofeng
Wong, Xisheng
Qiu, Guixing
Jiang, Baoguo
author_sort Kou, Yuhui
collection PubMed
description Effects of Epimedium extract and its constituent icariin on peripheral nerve repair were investigated in a crush injury rat model. Animals were divided into four groups: sham, control, Epimedium extract, and icariin groups. At postoperative weeks 1, 2, 4, and 8, nerve regeneration and functional recovery were evaluated by sciatic functional index (SFI), nerve electrophysiology, nerve pinch test, and muscle wet weight. Results showed that at 2 and 4 weeks after surgery rats in the Epimedium group displayed a better recovery of nerve function than that in the icariin and control groups, with better recovery in the icariin group than in the control group. The nerve pinch test showed that nerve regeneration was greater in the Epimedium group and the icariin group as compared to the control group. In addition, the muscle wet weight in the Epimedium group was significantly improved when compared with the icariin group, and the improvement in the icariin group was better than that in the control group at 8 weeks after operation. Our findings suggest that Epimedium extract effectively promotes peripheral nerve regeneration and improves the function of damaged nerves.
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spelling pubmed-37894162013-10-24 Epimedium Extract Promotes Peripheral Nerve Regeneration in Rats Kou, Yuhui Wang, Zhiyong Wu, Zhihong Zhang, Peixun Zhang, Yu Yin, Xiaofeng Wong, Xisheng Qiu, Guixing Jiang, Baoguo Evid Based Complement Alternat Med Research Article Effects of Epimedium extract and its constituent icariin on peripheral nerve repair were investigated in a crush injury rat model. Animals were divided into four groups: sham, control, Epimedium extract, and icariin groups. At postoperative weeks 1, 2, 4, and 8, nerve regeneration and functional recovery were evaluated by sciatic functional index (SFI), nerve electrophysiology, nerve pinch test, and muscle wet weight. Results showed that at 2 and 4 weeks after surgery rats in the Epimedium group displayed a better recovery of nerve function than that in the icariin and control groups, with better recovery in the icariin group than in the control group. The nerve pinch test showed that nerve regeneration was greater in the Epimedium group and the icariin group as compared to the control group. In addition, the muscle wet weight in the Epimedium group was significantly improved when compared with the icariin group, and the improvement in the icariin group was better than that in the control group at 8 weeks after operation. Our findings suggest that Epimedium extract effectively promotes peripheral nerve regeneration and improves the function of damaged nerves. Hindawi Publishing Corporation 2013 2013-09-17 /pmc/articles/PMC3789416/ /pubmed/24159356 http://dx.doi.org/10.1155/2013/954798 Text en Copyright © 2013 Yuhui Kou et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Kou, Yuhui
Wang, Zhiyong
Wu, Zhihong
Zhang, Peixun
Zhang, Yu
Yin, Xiaofeng
Wong, Xisheng
Qiu, Guixing
Jiang, Baoguo
Epimedium Extract Promotes Peripheral Nerve Regeneration in Rats
title Epimedium Extract Promotes Peripheral Nerve Regeneration in Rats
title_full Epimedium Extract Promotes Peripheral Nerve Regeneration in Rats
title_fullStr Epimedium Extract Promotes Peripheral Nerve Regeneration in Rats
title_full_unstemmed Epimedium Extract Promotes Peripheral Nerve Regeneration in Rats
title_short Epimedium Extract Promotes Peripheral Nerve Regeneration in Rats
title_sort epimedium extract promotes peripheral nerve regeneration in rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789416/
https://www.ncbi.nlm.nih.gov/pubmed/24159356
http://dx.doi.org/10.1155/2013/954798
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