Trimeric Tau Is Toxic to Human Neuronal Cells at Low Nanomolar Concentrations

In Alzheimer's disease (AD), tau aggregates into fibrils and higher order neurofibrillary tangles, a key histopathological feature of AD. However, soluble oligomeric tau species may play a more critical role in AD progression since these tau species correlate better with neuronal loss and cogni...

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Detalles Bibliográficos
Autores principales: Tian, Huilai, Davidowitz, Eliot, Lopez, Patricia, Emadi, Sharareh, Moe, James, Sierks, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789488/
https://www.ncbi.nlm.nih.gov/pubmed/24159335
http://dx.doi.org/10.1155/2013/260787

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789488/
https://www.ncbi.nlm.nih.gov/pubmed/24159335
http://dx.doi.org/10.1155/2013/260787

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