Cargando…

A Randomized Clinical Trial Comparing the Effect of Different Haemostatic Agents for Haemostasis of the Liver after Hepatic Resection

Introduction. Operative blood loss is still a great obstacle to liver resection, and various topical hemostatic agents were introduced to reduce it. The aim of the current study is to evaluate effects of 3 different types of these agents. Methods. In this randomized clinical trial, 45 patients under...

Descripción completa

Detalles Bibliográficos
Autores principales: Kakaei, Farzad, Seyyed Sadeghi, Mir Salim, Sanei, Behnam, Hashemzadeh, Shahryar, Habibzadeh, Afshin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789495/
https://www.ncbi.nlm.nih.gov/pubmed/24159254
http://dx.doi.org/10.1155/2013/587608
_version_ 1782286456407982080
author Kakaei, Farzad
Seyyed Sadeghi, Mir Salim
Sanei, Behnam
Hashemzadeh, Shahryar
Habibzadeh, Afshin
author_facet Kakaei, Farzad
Seyyed Sadeghi, Mir Salim
Sanei, Behnam
Hashemzadeh, Shahryar
Habibzadeh, Afshin
author_sort Kakaei, Farzad
collection PubMed
description Introduction. Operative blood loss is still a great obstacle to liver resection, and various topical hemostatic agents were introduced to reduce it. The aim of the current study is to evaluate effects of 3 different types of these agents. Methods. In this randomized clinical trial, 45 patients undergoing liver resection were assigned to receive TachoSil, Surgicel, and Glubran 2 for controlling bleeding. Intraoperative and postoperative findings were compared between groups. Results. Postoperative bleeding (0 versus 33.3%, P = 0.04) and drainage volume first day after surgery (281.33 ± 103.98 versus 150.00 ± 60.82 mL, P = 0.02) were significantly higher in Surgicel than in TachoSil group. Postoperative complications included bile leak (3 cases in Surgicel, 1 case in TachoSil and Glubran 2), noninfectious collection (2 cases in TachoSil and Surgicel and 1 case in Glubran 2), perihepatic abscess, and massive hematoma around hepatectomy site both in Surgicel group. There was no death during the study period. Conclusion. Due to higher complications in Surgicel group, its application as hemostatic agent after liver resection is not recommended. Better results in TachoSil in comparison to the other two are indicative of its better efficacy and superiority in controlling hemostasis.
format Online
Article
Text
id pubmed-3789495
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-37894952013-10-24 A Randomized Clinical Trial Comparing the Effect of Different Haemostatic Agents for Haemostasis of the Liver after Hepatic Resection Kakaei, Farzad Seyyed Sadeghi, Mir Salim Sanei, Behnam Hashemzadeh, Shahryar Habibzadeh, Afshin HPB Surg Clinical Study Introduction. Operative blood loss is still a great obstacle to liver resection, and various topical hemostatic agents were introduced to reduce it. The aim of the current study is to evaluate effects of 3 different types of these agents. Methods. In this randomized clinical trial, 45 patients undergoing liver resection were assigned to receive TachoSil, Surgicel, and Glubran 2 for controlling bleeding. Intraoperative and postoperative findings were compared between groups. Results. Postoperative bleeding (0 versus 33.3%, P = 0.04) and drainage volume first day after surgery (281.33 ± 103.98 versus 150.00 ± 60.82 mL, P = 0.02) were significantly higher in Surgicel than in TachoSil group. Postoperative complications included bile leak (3 cases in Surgicel, 1 case in TachoSil and Glubran 2), noninfectious collection (2 cases in TachoSil and Surgicel and 1 case in Glubran 2), perihepatic abscess, and massive hematoma around hepatectomy site both in Surgicel group. There was no death during the study period. Conclusion. Due to higher complications in Surgicel group, its application as hemostatic agent after liver resection is not recommended. Better results in TachoSil in comparison to the other two are indicative of its better efficacy and superiority in controlling hemostasis. Hindawi Publishing Corporation 2013 2013-09-17 /pmc/articles/PMC3789495/ /pubmed/24159254 http://dx.doi.org/10.1155/2013/587608 Text en Copyright © 2013 Farzad Kakaei et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Kakaei, Farzad
Seyyed Sadeghi, Mir Salim
Sanei, Behnam
Hashemzadeh, Shahryar
Habibzadeh, Afshin
A Randomized Clinical Trial Comparing the Effect of Different Haemostatic Agents for Haemostasis of the Liver after Hepatic Resection
title A Randomized Clinical Trial Comparing the Effect of Different Haemostatic Agents for Haemostasis of the Liver after Hepatic Resection
title_full A Randomized Clinical Trial Comparing the Effect of Different Haemostatic Agents for Haemostasis of the Liver after Hepatic Resection
title_fullStr A Randomized Clinical Trial Comparing the Effect of Different Haemostatic Agents for Haemostasis of the Liver after Hepatic Resection
title_full_unstemmed A Randomized Clinical Trial Comparing the Effect of Different Haemostatic Agents for Haemostasis of the Liver after Hepatic Resection
title_short A Randomized Clinical Trial Comparing the Effect of Different Haemostatic Agents for Haemostasis of the Liver after Hepatic Resection
title_sort randomized clinical trial comparing the effect of different haemostatic agents for haemostasis of the liver after hepatic resection
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789495/
https://www.ncbi.nlm.nih.gov/pubmed/24159254
http://dx.doi.org/10.1155/2013/587608
work_keys_str_mv AT kakaeifarzad arandomizedclinicaltrialcomparingtheeffectofdifferenthaemostaticagentsforhaemostasisoftheliverafterhepaticresection
AT seyyedsadeghimirsalim arandomizedclinicaltrialcomparingtheeffectofdifferenthaemostaticagentsforhaemostasisoftheliverafterhepaticresection
AT saneibehnam arandomizedclinicaltrialcomparingtheeffectofdifferenthaemostaticagentsforhaemostasisoftheliverafterhepaticresection
AT hashemzadehshahryar arandomizedclinicaltrialcomparingtheeffectofdifferenthaemostaticagentsforhaemostasisoftheliverafterhepaticresection
AT habibzadehafshin arandomizedclinicaltrialcomparingtheeffectofdifferenthaemostaticagentsforhaemostasisoftheliverafterhepaticresection
AT kakaeifarzad randomizedclinicaltrialcomparingtheeffectofdifferenthaemostaticagentsforhaemostasisoftheliverafterhepaticresection
AT seyyedsadeghimirsalim randomizedclinicaltrialcomparingtheeffectofdifferenthaemostaticagentsforhaemostasisoftheliverafterhepaticresection
AT saneibehnam randomizedclinicaltrialcomparingtheeffectofdifferenthaemostaticagentsforhaemostasisoftheliverafterhepaticresection
AT hashemzadehshahryar randomizedclinicaltrialcomparingtheeffectofdifferenthaemostaticagentsforhaemostasisoftheliverafterhepaticresection
AT habibzadehafshin randomizedclinicaltrialcomparingtheeffectofdifferenthaemostaticagentsforhaemostasisoftheliverafterhepaticresection