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Correction of Hypothyroidism Seems to Have No Effect on Body Fat

Aim. We aimed to observe the effects of L-thyroxine replacement therapy on body fat content determined with various anthropometric methods and a bioelectrical impedance analysis method in patients with hypothyroidism. Methods. Forty-two women with naive autoimmune hypothyroidism were included. Also,...

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Autores principales: Bakiner, Okan, Bozkirli, Emre, Ersozlu Bozkirli, Emine Duygu, Ozsahin, Kursat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789500/
https://www.ncbi.nlm.nih.gov/pubmed/24159332
http://dx.doi.org/10.1155/2013/576794
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author Bakiner, Okan
Bozkirli, Emre
Ersozlu Bozkirli, Emine Duygu
Ozsahin, Kursat
author_facet Bakiner, Okan
Bozkirli, Emre
Ersozlu Bozkirli, Emine Duygu
Ozsahin, Kursat
author_sort Bakiner, Okan
collection PubMed
description Aim. We aimed to observe the effects of L-thyroxine replacement therapy on body fat content determined with various anthropometric methods and a bioelectrical impedance analysis method in patients with hypothyroidism. Methods. Forty-two women with naive autoimmune hypothyroidism were included. Also, 40 healthy participants were enrolled as a control group. Weight, body mass index, waist circumference, and subscapulary, suprailiac, femur, biceps, and triceps skin fold thicknesses were measured. Body fat percentages were calculated and body fat measurements were performed. Euthyroidism was maintained with L-thyroxine. At the 6th and 18th month, of therapy, measurements were reperformed. Results. Mean TSH levels were 57.49 ± 36.46 mIU/L in hypothyroid group and 1.94 ± 1.12 mIU/L in control subjects at admission. In hypothyroid patients, calculated body fat percentages were greater than those of the control subjects during follow-up. Body fat percentage of each hypothyroid case decreased at 6- and 18-month controls, but the decrements were statistically insignificant. Although skin fold thicknesses measured from all sites were observed to decline, only those obtained from femur and biceps showed a significant decrease (P = 0.03 and P = 0.01, resp.). Discussion. Correction of hypothyroidism did not cause any improvement in body weight and body fat percentage. The decrease in skin fold thicknesses might probably result from the reduction in subcutaneous mucopolysaccharide deposits.
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spelling pubmed-37895002013-10-24 Correction of Hypothyroidism Seems to Have No Effect on Body Fat Bakiner, Okan Bozkirli, Emre Ersozlu Bozkirli, Emine Duygu Ozsahin, Kursat Int J Endocrinol Clinical Study Aim. We aimed to observe the effects of L-thyroxine replacement therapy on body fat content determined with various anthropometric methods and a bioelectrical impedance analysis method in patients with hypothyroidism. Methods. Forty-two women with naive autoimmune hypothyroidism were included. Also, 40 healthy participants were enrolled as a control group. Weight, body mass index, waist circumference, and subscapulary, suprailiac, femur, biceps, and triceps skin fold thicknesses were measured. Body fat percentages were calculated and body fat measurements were performed. Euthyroidism was maintained with L-thyroxine. At the 6th and 18th month, of therapy, measurements were reperformed. Results. Mean TSH levels were 57.49 ± 36.46 mIU/L in hypothyroid group and 1.94 ± 1.12 mIU/L in control subjects at admission. In hypothyroid patients, calculated body fat percentages were greater than those of the control subjects during follow-up. Body fat percentage of each hypothyroid case decreased at 6- and 18-month controls, but the decrements were statistically insignificant. Although skin fold thicknesses measured from all sites were observed to decline, only those obtained from femur and biceps showed a significant decrease (P = 0.03 and P = 0.01, resp.). Discussion. Correction of hypothyroidism did not cause any improvement in body weight and body fat percentage. The decrease in skin fold thicknesses might probably result from the reduction in subcutaneous mucopolysaccharide deposits. Hindawi Publishing Corporation 2013 2013-09-17 /pmc/articles/PMC3789500/ /pubmed/24159332 http://dx.doi.org/10.1155/2013/576794 Text en Copyright © 2013 Okan Bakiner et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Bakiner, Okan
Bozkirli, Emre
Ersozlu Bozkirli, Emine Duygu
Ozsahin, Kursat
Correction of Hypothyroidism Seems to Have No Effect on Body Fat
title Correction of Hypothyroidism Seems to Have No Effect on Body Fat
title_full Correction of Hypothyroidism Seems to Have No Effect on Body Fat
title_fullStr Correction of Hypothyroidism Seems to Have No Effect on Body Fat
title_full_unstemmed Correction of Hypothyroidism Seems to Have No Effect on Body Fat
title_short Correction of Hypothyroidism Seems to Have No Effect on Body Fat
title_sort correction of hypothyroidism seems to have no effect on body fat
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789500/
https://www.ncbi.nlm.nih.gov/pubmed/24159332
http://dx.doi.org/10.1155/2013/576794
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