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The Heme Oxygenase-1 Inducer THI-56 Negatively Regulates iNOS Expression and HMGB1 Release in LPS-Activated RAW 264.7 Cells and CLP-Induced Septic Mice

The nuclear DNA binding protein high mobility group box 1 (HMGB1) has recently been suggested to act as a late mediator of septic shock. The effect of ((S)-6,7-dihydroxy-1-(4-hydroxynaphthylmethyl)-1,2,3,4-tetrahydroisoquinoline alkaloid, also known as THI-56, in an experimental model of sepsis was...

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Detalles Bibliográficos
Autores principales:	Park, Eun Jung, Jang, Hwa Jin, Tsoyi, Konstantin, Kim, Young Min, Park, Sang Won, Kim, Hye Jung, Lee, Jae Heun, Chang, Ki Churl
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789711/ https://www.ncbi.nlm.nih.gov/pubmed/24098466 http://dx.doi.org/10.1371/journal.pone.0076293

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