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Regulation of Mammalian Autophagy by Class II and III PI 3-Kinases through PI3P Synthesis

Synthesis of phosphatidylinositol-3-phosphate (PI3P) by Vps34, a class III phosphatidylinositol 3-kinase (PI3K), is critical for the initial steps of autophagosome (AP) biogenesis. Although Vps34 is the sole source of PI3P in budding yeast, mammalian cells can produce PI3P through alternate pathways...

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Detalles Bibliográficos
Autores principales:	Devereaux, Kelly, Dall’Armi, Claudia, Alcazar-Roman, Abel, Ogasawara, Yuta, Zhou, Xiang, Wang, Fan, Yamamoto, Akitsugu, De Camilli, Pietro, Di Paolo, Gilbert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789715/ https://www.ncbi.nlm.nih.gov/pubmed/24098492 http://dx.doi.org/10.1371/journal.pone.0076405

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