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Creatine Supplementation Associated or Not with Strength Training upon Emotional and Cognitive Measures in Older Women: A Randomized Double-Blind Study

PURPOSE: To assess the effects of creatine supplementation, associated or not with strength training, upon emotional and cognitive measures in older woman. METHODS: This is a 24-week, parallel-group, double-blind, randomized, placebo-controlled trial. The individuals were randomly allocated into one...

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Autores principales: Alves, Christiano Robles Rodrigues, Merege Filho, Carlos Alberto Abujabra, Benatti, Fabiana Braga, Brucki, Sonia, Pereira, Rosa Maria R., de Sá Pinto, Ana Lucia, Lima, Fernanda Rodrigues, Roschel, Hamilton, Gualano, Bruno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789718/
https://www.ncbi.nlm.nih.gov/pubmed/24098469
http://dx.doi.org/10.1371/journal.pone.0076301
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author Alves, Christiano Robles Rodrigues
Merege Filho, Carlos Alberto Abujabra
Benatti, Fabiana Braga
Brucki, Sonia
Pereira, Rosa Maria R.
de Sá Pinto, Ana Lucia
Lima, Fernanda Rodrigues
Roschel, Hamilton
Gualano, Bruno
author_facet Alves, Christiano Robles Rodrigues
Merege Filho, Carlos Alberto Abujabra
Benatti, Fabiana Braga
Brucki, Sonia
Pereira, Rosa Maria R.
de Sá Pinto, Ana Lucia
Lima, Fernanda Rodrigues
Roschel, Hamilton
Gualano, Bruno
author_sort Alves, Christiano Robles Rodrigues
collection PubMed
description PURPOSE: To assess the effects of creatine supplementation, associated or not with strength training, upon emotional and cognitive measures in older woman. METHODS: This is a 24-week, parallel-group, double-blind, randomized, placebo-controlled trial. The individuals were randomly allocated into one of the following groups (n=14 each): 1) placebo, 2) creatine supplementation, 3) placebo associated with strength training or 4) creatine supplementation associated with strength training. According to their allocation, the participants were given creatine (4 x 5 g/d for 5 days followed by 5 g/d) or placebo (dextrose at the same dosage) and were strength trained or not. Cognitive function, assessed by a comprehensive battery of tests involving memory, selective attention, and inhibitory control, and emotional measures, assessed by the Geriatric Depression Scale, were evaluated at baseline, after 12 and 24 weeks of the intervention. Muscle strength and food intake were evaluated at baseline and after 24 weeks. RESULTS: After the 24-week intervention, both training groups (ingesting creatine supplementation and placebo) had significant reductions on the Geriatric Depression Scale scores when compared with the non-trained placebo group (p = 0.001 and p = 0.01, respectively) and the non-trained creatine group (p < 0.001 for both comparison). However, no significant differences were observed between the non-trained placebo and creatine (p = 0.60) groups, or between the trained placebo and creatine groups (p = 0.83). Both trained groups, irrespective of creatine supplementation, had better muscle strength performance than the non-trained groups. Neither strength training nor creatine supplementation altered any parameter of cognitive performance. Food intake remained unchanged. CONCLUSION: Creatine supplementation did not promote any significant change in cognitive function and emotional parameters in apparently healthy older individuals. In addition, strength training per se improved emotional state and muscle strength, but not cognition, with no additive effects of creatine supplementation. TRIAL REGISTRATION: Clinicaltrials.gov NCT01164020
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spelling pubmed-37897182013-10-04 Creatine Supplementation Associated or Not with Strength Training upon Emotional and Cognitive Measures in Older Women: A Randomized Double-Blind Study Alves, Christiano Robles Rodrigues Merege Filho, Carlos Alberto Abujabra Benatti, Fabiana Braga Brucki, Sonia Pereira, Rosa Maria R. de Sá Pinto, Ana Lucia Lima, Fernanda Rodrigues Roschel, Hamilton Gualano, Bruno PLoS One Research Article PURPOSE: To assess the effects of creatine supplementation, associated or not with strength training, upon emotional and cognitive measures in older woman. METHODS: This is a 24-week, parallel-group, double-blind, randomized, placebo-controlled trial. The individuals were randomly allocated into one of the following groups (n=14 each): 1) placebo, 2) creatine supplementation, 3) placebo associated with strength training or 4) creatine supplementation associated with strength training. According to their allocation, the participants were given creatine (4 x 5 g/d for 5 days followed by 5 g/d) or placebo (dextrose at the same dosage) and were strength trained or not. Cognitive function, assessed by a comprehensive battery of tests involving memory, selective attention, and inhibitory control, and emotional measures, assessed by the Geriatric Depression Scale, were evaluated at baseline, after 12 and 24 weeks of the intervention. Muscle strength and food intake were evaluated at baseline and after 24 weeks. RESULTS: After the 24-week intervention, both training groups (ingesting creatine supplementation and placebo) had significant reductions on the Geriatric Depression Scale scores when compared with the non-trained placebo group (p = 0.001 and p = 0.01, respectively) and the non-trained creatine group (p < 0.001 for both comparison). However, no significant differences were observed between the non-trained placebo and creatine (p = 0.60) groups, or between the trained placebo and creatine groups (p = 0.83). Both trained groups, irrespective of creatine supplementation, had better muscle strength performance than the non-trained groups. Neither strength training nor creatine supplementation altered any parameter of cognitive performance. Food intake remained unchanged. CONCLUSION: Creatine supplementation did not promote any significant change in cognitive function and emotional parameters in apparently healthy older individuals. In addition, strength training per se improved emotional state and muscle strength, but not cognition, with no additive effects of creatine supplementation. TRIAL REGISTRATION: Clinicaltrials.gov NCT01164020 Public Library of Science 2013-10-03 /pmc/articles/PMC3789718/ /pubmed/24098469 http://dx.doi.org/10.1371/journal.pone.0076301 Text en © 2013 Alves et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Alves, Christiano Robles Rodrigues
Merege Filho, Carlos Alberto Abujabra
Benatti, Fabiana Braga
Brucki, Sonia
Pereira, Rosa Maria R.
de Sá Pinto, Ana Lucia
Lima, Fernanda Rodrigues
Roschel, Hamilton
Gualano, Bruno
Creatine Supplementation Associated or Not with Strength Training upon Emotional and Cognitive Measures in Older Women: A Randomized Double-Blind Study
title Creatine Supplementation Associated or Not with Strength Training upon Emotional and Cognitive Measures in Older Women: A Randomized Double-Blind Study
title_full Creatine Supplementation Associated or Not with Strength Training upon Emotional and Cognitive Measures in Older Women: A Randomized Double-Blind Study
title_fullStr Creatine Supplementation Associated or Not with Strength Training upon Emotional and Cognitive Measures in Older Women: A Randomized Double-Blind Study
title_full_unstemmed Creatine Supplementation Associated or Not with Strength Training upon Emotional and Cognitive Measures in Older Women: A Randomized Double-Blind Study
title_short Creatine Supplementation Associated or Not with Strength Training upon Emotional and Cognitive Measures in Older Women: A Randomized Double-Blind Study
title_sort creatine supplementation associated or not with strength training upon emotional and cognitive measures in older women: a randomized double-blind study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789718/
https://www.ncbi.nlm.nih.gov/pubmed/24098469
http://dx.doi.org/10.1371/journal.pone.0076301
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