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Human Papillomavirus Prevalence in a Population of Women Living in Port-au-Prince and Leogane, Haiti

BACKGROUND: There have been no published studies of carcinogenic human papillomavirus (HPV)--the necessary cause of cervical cancer--in Haiti, a nation that has one of the greatest burdens of cervical cancer globally. OBJECTIVE: Characterize prevalence of carcinogenic HPV and the prevalence of indiv...

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Autores principales: Walmer, David K., Eder, Paul S., Bell, Laura, Salim, Hiam, Kobayashi, Lori, Ndirangu, Jackie, Tinfo, Nicole, Castle, Philip E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789741/
https://www.ncbi.nlm.nih.gov/pubmed/24098429
http://dx.doi.org/10.1371/journal.pone.0076110
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author Walmer, David K.
Eder, Paul S.
Bell, Laura
Salim, Hiam
Kobayashi, Lori
Ndirangu, Jackie
Tinfo, Nicole
Castle, Philip E.
author_facet Walmer, David K.
Eder, Paul S.
Bell, Laura
Salim, Hiam
Kobayashi, Lori
Ndirangu, Jackie
Tinfo, Nicole
Castle, Philip E.
author_sort Walmer, David K.
collection PubMed
description BACKGROUND: There have been no published studies of carcinogenic human papillomavirus (HPV)--the necessary cause of cervical cancer--in Haiti, a nation that has one of the greatest burdens of cervical cancer globally. OBJECTIVE: Characterize prevalence of carcinogenic HPV and the prevalence of individual carcinogenic HPV genotypes in women with cervical precancer or cancer, cervical intraepithelial neoplasia grade 2 (CIN2) or more severe (CIN2+). METHODS: Women (n=9,769; aged 25-60 years) were screened for carcinogenic HPV by Hybrid Capture 2 (HC2; Qiagen, Gaithersburg, MD). Carcinogenic HPV positives underwent colposcopy and visible lesions were biopsied. A subset of carcinogenic HPV positives was tested for individual HPV genotypes using a GP5+/6+ assay. RESULTS: The prevalence of carcinogenic HPV was 19.0% (95% confidence interval: 18.4%-19.9%) and decreased with increasing age (p(trend) < 0.001). Women with 3 or more sexual partners and who started sex before the age of 18 years had twice the age-adjusted prevalence of carcinogenic HPV of women with one partner and who started sex after the age of 21 (24.3% vs. 12.9%, respectively). HPV16 and HPV35 were the most common HPV genotypes detected in CIN2+ and more common in women with CIN2+ than those without CIN2+. HPV16 and/or HPV18 were detected in 21.0% of CIN2 (n = 42), 46.2% of CIN3 (n = 52), and 80% of cancers (n = 5). CONCLUSIONS: The prevalence of carcinogenic HPV in Haiti was much greater than the prevalence in other Latin American countries. High carcinogenic HPV prevalence and a lack of cervical cancer screening may explain the high burden of cervical cancer in Haiti.
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spelling pubmed-37897412013-10-04 Human Papillomavirus Prevalence in a Population of Women Living in Port-au-Prince and Leogane, Haiti Walmer, David K. Eder, Paul S. Bell, Laura Salim, Hiam Kobayashi, Lori Ndirangu, Jackie Tinfo, Nicole Castle, Philip E. PLoS One Research Article BACKGROUND: There have been no published studies of carcinogenic human papillomavirus (HPV)--the necessary cause of cervical cancer--in Haiti, a nation that has one of the greatest burdens of cervical cancer globally. OBJECTIVE: Characterize prevalence of carcinogenic HPV and the prevalence of individual carcinogenic HPV genotypes in women with cervical precancer or cancer, cervical intraepithelial neoplasia grade 2 (CIN2) or more severe (CIN2+). METHODS: Women (n=9,769; aged 25-60 years) were screened for carcinogenic HPV by Hybrid Capture 2 (HC2; Qiagen, Gaithersburg, MD). Carcinogenic HPV positives underwent colposcopy and visible lesions were biopsied. A subset of carcinogenic HPV positives was tested for individual HPV genotypes using a GP5+/6+ assay. RESULTS: The prevalence of carcinogenic HPV was 19.0% (95% confidence interval: 18.4%-19.9%) and decreased with increasing age (p(trend) < 0.001). Women with 3 or more sexual partners and who started sex before the age of 18 years had twice the age-adjusted prevalence of carcinogenic HPV of women with one partner and who started sex after the age of 21 (24.3% vs. 12.9%, respectively). HPV16 and HPV35 were the most common HPV genotypes detected in CIN2+ and more common in women with CIN2+ than those without CIN2+. HPV16 and/or HPV18 were detected in 21.0% of CIN2 (n = 42), 46.2% of CIN3 (n = 52), and 80% of cancers (n = 5). CONCLUSIONS: The prevalence of carcinogenic HPV in Haiti was much greater than the prevalence in other Latin American countries. High carcinogenic HPV prevalence and a lack of cervical cancer screening may explain the high burden of cervical cancer in Haiti. Public Library of Science 2013-10-03 /pmc/articles/PMC3789741/ /pubmed/24098429 http://dx.doi.org/10.1371/journal.pone.0076110 Text en © 2013 Walmer et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Walmer, David K.
Eder, Paul S.
Bell, Laura
Salim, Hiam
Kobayashi, Lori
Ndirangu, Jackie
Tinfo, Nicole
Castle, Philip E.
Human Papillomavirus Prevalence in a Population of Women Living in Port-au-Prince and Leogane, Haiti
title Human Papillomavirus Prevalence in a Population of Women Living in Port-au-Prince and Leogane, Haiti
title_full Human Papillomavirus Prevalence in a Population of Women Living in Port-au-Prince and Leogane, Haiti
title_fullStr Human Papillomavirus Prevalence in a Population of Women Living in Port-au-Prince and Leogane, Haiti
title_full_unstemmed Human Papillomavirus Prevalence in a Population of Women Living in Port-au-Prince and Leogane, Haiti
title_short Human Papillomavirus Prevalence in a Population of Women Living in Port-au-Prince and Leogane, Haiti
title_sort human papillomavirus prevalence in a population of women living in port-au-prince and leogane, haiti
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789741/
https://www.ncbi.nlm.nih.gov/pubmed/24098429
http://dx.doi.org/10.1371/journal.pone.0076110
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