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Herpes Simplex Virus Type 1 Single Strand DNA Binding Protein and Helicase/Primase Complex Disable Cellular ATR Signaling

Herpes Simplex Virus type 1 (HSV-1) has evolved to disable the cellular DNA damage response kinase, ATR. We have previously shown that HSV-1-infected cells are unable to phosphorylate the ATR substrate Chk1, even under conditions in which replication forks are stalled. Here we report that the HSV-1...

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Detalles Bibliográficos
Autores principales:	Mohni, Kareem N., Smith, Samantha, Dee, Alexander R., Schumacher, April J., Weller, Sandra K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789782/ https://www.ncbi.nlm.nih.gov/pubmed/24098119 http://dx.doi.org/10.1371/journal.ppat.1003652

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