The C-terminal Residues of Saccharomyces cerevisiae Mec1 Are Required for Its Localization, Stability, and Function

Mec1, a member of the phosphoinositide three-kinase-related kinase (PIKK) family of proteins, is involved in the response to replicative stress and DNA damage and in telomere maintenance. An essential 30 to 35 residue, the FATC domain is found at the C-terminus of all PIKK family members. To investi...

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Detalles Bibliográficos
Autores principales: DaSilva, Lance F., Pillon, Samantha, Genereaux, Julie, Davey, Megan J., Gloor, Gregory B., Karagiannis, Jim, Brandl, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2013
Materias:
Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789791/
https://www.ncbi.nlm.nih.gov/pubmed/23934994
http://dx.doi.org/10.1534/g3.113.006841

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789791/
https://www.ncbi.nlm.nih.gov/pubmed/23934994
http://dx.doi.org/10.1534/g3.113.006841

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