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Direct Monitoring of the Strand Passage Reaction of DNA Topoisomerase II Triggers Checkpoint Activation

By necessity, the ancient activity of type II topoisomerases co-evolved with the double-helical structure of DNA, at least in organisms with circular genomes. In humans, the strand passage reaction of DNA topoisomerase II (Topo II) is the target of several major classes of cancer drugs which both po...

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Detalles Bibliográficos
Autores principales:	Furniss, Katherine L., Tsai, Hung-Ji, Byl, Jo Ann W., Lane, Andrew B., Vas, Amit C., Hsu, Wei-Shan, Osheroff, Neil, Clarke, Duncan J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789831/ https://www.ncbi.nlm.nih.gov/pubmed/24098144 http://dx.doi.org/10.1371/journal.pgen.1003832

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