A Mutation in the SUV39H2 Gene in Labrador Retrievers with Hereditary Nasal Parakeratosis (HNPK) Provides Insights into the Epigenetics of Keratinocyte Differentiation

Hereditary nasal parakeratosis (HNPK), an inherited monogenic autosomal recessive skin disorder, leads to crusts and fissures on the nasal planum of Labrador Retrievers. We performed a genome-wide association study (GWAS) using 13 HNPK cases and 23 controls. We obtained a single strong association s...

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Detalles Bibliográficos
Autores principales: Jagannathan, Vidhya, Bannoehr, Jeanette, Plattet, Philippe, Hauswirth, Regula, Drögemüller, Cord, Drögemüller, Michaela, Wiener, Dominique J., Doherr, Marcus, Owczarek-Lipska, Marta, Galichet, Arnaud, Welle, Monika M., Tengvall, Katarina, Bergvall, Kerstin, Lohi, Hannes, Rüfenacht, Silvia, Linek, Monika, Paradis, Manon, Müller, Eliane J., Roosje, Petra, Leeb, Tosso
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789836/
https://www.ncbi.nlm.nih.gov/pubmed/24098150
http://dx.doi.org/10.1371/journal.pgen.1003848

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