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Isolated Cervical Lymph Node Sarcoidosis Presenting in an Asymptomatic Neck Mass: A Case Report
Sarcoidosis, a systemic granulomatous disease of unknown etiology. The presentation of sarcoidal granuloma in neck nodes without typical manifestations of systemic sarcoidosis is difficult to diagnose. We describe the case of a 37-year-old woman with an increasing mass on the right side of neck. The...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Korean Academy of Tuberculosis and Respiratory Diseases
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790023/ https://www.ncbi.nlm.nih.gov/pubmed/24101936 http://dx.doi.org/10.4046/trd.2013.75.3.116 |
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author | Kwon, Yong Shik Jung, Hye In Kim, Hyun Jung Lee, Jin Wook Choi, Won-Il Kim, Jin Young Rho, Byung Hak Lee, Hye Won Kwon, Kun Young |
author_facet | Kwon, Yong Shik Jung, Hye In Kim, Hyun Jung Lee, Jin Wook Choi, Won-Il Kim, Jin Young Rho, Byung Hak Lee, Hye Won Kwon, Kun Young |
author_sort | Kwon, Yong Shik |
collection | PubMed |
description | Sarcoidosis, a systemic granulomatous disease of unknown etiology. The presentation of sarcoidal granuloma in neck nodes without typical manifestations of systemic sarcoidosis is difficult to diagnose. We describe the case of a 37-year-old woman with an increasing mass on the right side of neck. The excisional biopsy from the neck mass showed noncaseating epithelioid cell granuloma of the lymph nodes. No evidence of mycobacterial or fungal infection was noted. Thoracic evaluations did not show enlargement of mediastinal lymph nodes or parenchymal abnormalities. Immunohistochemistry showed abundant expression of tumor necrosis factor-α in the granuloma. However, transforming growth factor-β was not expressed, although interleukin-1β was focally expressed. These immunohistochemical findings supported characterization of the granuloma and the diagnosis of sarcoidosis. Sarcoidosis can present with cervical lymph node enlargement without mediastinal or lung abnormality. Immunohistochemistry may support the diagnosis of sarcoidosis and characterization of granuloma. |
format | Online Article Text |
id | pubmed-3790023 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | The Korean Academy of Tuberculosis and Respiratory Diseases |
record_format | MEDLINE/PubMed |
spelling | pubmed-37900232013-10-07 Isolated Cervical Lymph Node Sarcoidosis Presenting in an Asymptomatic Neck Mass: A Case Report Kwon, Yong Shik Jung, Hye In Kim, Hyun Jung Lee, Jin Wook Choi, Won-Il Kim, Jin Young Rho, Byung Hak Lee, Hye Won Kwon, Kun Young Tuberc Respir Dis (Seoul) Case Report Sarcoidosis, a systemic granulomatous disease of unknown etiology. The presentation of sarcoidal granuloma in neck nodes without typical manifestations of systemic sarcoidosis is difficult to diagnose. We describe the case of a 37-year-old woman with an increasing mass on the right side of neck. The excisional biopsy from the neck mass showed noncaseating epithelioid cell granuloma of the lymph nodes. No evidence of mycobacterial or fungal infection was noted. Thoracic evaluations did not show enlargement of mediastinal lymph nodes or parenchymal abnormalities. Immunohistochemistry showed abundant expression of tumor necrosis factor-α in the granuloma. However, transforming growth factor-β was not expressed, although interleukin-1β was focally expressed. These immunohistochemical findings supported characterization of the granuloma and the diagnosis of sarcoidosis. Sarcoidosis can present with cervical lymph node enlargement without mediastinal or lung abnormality. Immunohistochemistry may support the diagnosis of sarcoidosis and characterization of granuloma. The Korean Academy of Tuberculosis and Respiratory Diseases 2013-09 2013-09-30 /pmc/articles/PMC3790023/ /pubmed/24101936 http://dx.doi.org/10.4046/trd.2013.75.3.116 Text en Copyright©2013. The Korean Academy of Tuberculosis and Respiratory Diseases. All rights reserved. http://creativecommons.org/licenses/by-nc/3.0/ It is identical to the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) |
spellingShingle | Case Report Kwon, Yong Shik Jung, Hye In Kim, Hyun Jung Lee, Jin Wook Choi, Won-Il Kim, Jin Young Rho, Byung Hak Lee, Hye Won Kwon, Kun Young Isolated Cervical Lymph Node Sarcoidosis Presenting in an Asymptomatic Neck Mass: A Case Report |
title | Isolated Cervical Lymph Node Sarcoidosis Presenting in an Asymptomatic Neck Mass: A Case Report |
title_full | Isolated Cervical Lymph Node Sarcoidosis Presenting in an Asymptomatic Neck Mass: A Case Report |
title_fullStr | Isolated Cervical Lymph Node Sarcoidosis Presenting in an Asymptomatic Neck Mass: A Case Report |
title_full_unstemmed | Isolated Cervical Lymph Node Sarcoidosis Presenting in an Asymptomatic Neck Mass: A Case Report |
title_short | Isolated Cervical Lymph Node Sarcoidosis Presenting in an Asymptomatic Neck Mass: A Case Report |
title_sort | isolated cervical lymph node sarcoidosis presenting in an asymptomatic neck mass: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790023/ https://www.ncbi.nlm.nih.gov/pubmed/24101936 http://dx.doi.org/10.4046/trd.2013.75.3.116 |
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