IP(3)R1 deficiency in the cerebellum/brainstem causes basal ganglia-independent dystonia by triggering tonic Purkinje cell firings in mice

The type 1 inositol 1,4,5- trisphosphate receptor (IP(3)R1) is a Ca(2+) channel on the endoplasmic reticulum and is a predominant isoform in the brain among the three types of IP(3)Rs. Mice lacking IP(3)R1 show seizure-like behavior; however the cellular and neural circuit mechanism by which IP(3)R1...

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Detalles Bibliográficos
Autores principales: Hisatsune, Chihiro, Miyamoto, Hiroyuki, Hirono, Moritoshi, Yamaguchi, Naohide, Sugawara, Takeyuki, Ogawa, Naoko, Ebisui, Etsuko, Ohshima, Toshio, Yamada, Masahisa, Hensch, Takao K., Hattori, Mitsuharu, Mikoshiba, Katsuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790101/
https://www.ncbi.nlm.nih.gov/pubmed/24109434
http://dx.doi.org/10.3389/fncir.2013.00156

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