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Impairments of Motor-Cortex Responses to Unilateral and Bilateral Direct Current Stimulation in Schizophrenia

Transcranial direct current stimulation (tDCS) is a non-invasive stimulation technique that can be applied to modulate cortical activity through induction of cortical plasticity. Since various neuropsychiatric disorders are characterized by fluctuations in cortical activity levels (e.g., schizophren...

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Autores principales: Hasan, Alkomiet, Bergener, Theresa, Nitsche, Michael A., Strube, Wolfgang, Bunse, Tilmann, Falkai, Peter, Wobrock, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790105/
https://www.ncbi.nlm.nih.gov/pubmed/24109457
http://dx.doi.org/10.3389/fpsyt.2013.00121
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author Hasan, Alkomiet
Bergener, Theresa
Nitsche, Michael A.
Strube, Wolfgang
Bunse, Tilmann
Falkai, Peter
Wobrock, Thomas
author_facet Hasan, Alkomiet
Bergener, Theresa
Nitsche, Michael A.
Strube, Wolfgang
Bunse, Tilmann
Falkai, Peter
Wobrock, Thomas
author_sort Hasan, Alkomiet
collection PubMed
description Transcranial direct current stimulation (tDCS) is a non-invasive stimulation technique that can be applied to modulate cortical activity through induction of cortical plasticity. Since various neuropsychiatric disorders are characterized by fluctuations in cortical activity levels (e.g., schizophrenia), tDCS is increasingly investigated as a treatment tool. Several studies have shown that the induction of cortical plasticity following classical, unilateral tDCS is reduced or impaired in the stimulated and non-stimulated primary motor cortices (M1) of patients with schizophrenia. Moreover, an alternative, bilateral tDCS setup has recently been shown to modulate cortical plasticity in both hemispheres in healthy subjects, highlighting another potential treatment approach. Here we present the first study comparing the efficacy of unilateral tDCS (cathode left M1, anode right supraorbital) with simultaneous bilateral tDCS (cathode left M1, anode right M1) in patients with schizophrenia. tDCS-induced cortical plasticity was monitored by investigating motor-evoked potentials induced by single-pulse transcranial magnetic stimulation applied to both hemispheres. Healthy subjects showed a reduction of left M1 excitability following unilateral tDCS on the stimulated left hemisphere and an increase in right M1 excitability following bilateral tDCS. In schizophrenia, no plasticity was induced following both stimulation paradigms. The pattern of these results indicates a complex interplay between plasticity and connectivity that is impaired in patients with schizophrenia. Further studies are needed to clarify the biological underpinnings and clinical impact of these findings.
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spelling pubmed-37901052013-10-09 Impairments of Motor-Cortex Responses to Unilateral and Bilateral Direct Current Stimulation in Schizophrenia Hasan, Alkomiet Bergener, Theresa Nitsche, Michael A. Strube, Wolfgang Bunse, Tilmann Falkai, Peter Wobrock, Thomas Front Psychiatry Psychiatry Transcranial direct current stimulation (tDCS) is a non-invasive stimulation technique that can be applied to modulate cortical activity through induction of cortical plasticity. Since various neuropsychiatric disorders are characterized by fluctuations in cortical activity levels (e.g., schizophrenia), tDCS is increasingly investigated as a treatment tool. Several studies have shown that the induction of cortical plasticity following classical, unilateral tDCS is reduced or impaired in the stimulated and non-stimulated primary motor cortices (M1) of patients with schizophrenia. Moreover, an alternative, bilateral tDCS setup has recently been shown to modulate cortical plasticity in both hemispheres in healthy subjects, highlighting another potential treatment approach. Here we present the first study comparing the efficacy of unilateral tDCS (cathode left M1, anode right supraorbital) with simultaneous bilateral tDCS (cathode left M1, anode right M1) in patients with schizophrenia. tDCS-induced cortical plasticity was monitored by investigating motor-evoked potentials induced by single-pulse transcranial magnetic stimulation applied to both hemispheres. Healthy subjects showed a reduction of left M1 excitability following unilateral tDCS on the stimulated left hemisphere and an increase in right M1 excitability following bilateral tDCS. In schizophrenia, no plasticity was induced following both stimulation paradigms. The pattern of these results indicates a complex interplay between plasticity and connectivity that is impaired in patients with schizophrenia. Further studies are needed to clarify the biological underpinnings and clinical impact of these findings. Frontiers Media S.A. 2013-10-04 /pmc/articles/PMC3790105/ /pubmed/24109457 http://dx.doi.org/10.3389/fpsyt.2013.00121 Text en Copyright © 2013 Hasan, Bergener, Nitsche, Strube, Bunse, Falkai and Wobrock. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Hasan, Alkomiet
Bergener, Theresa
Nitsche, Michael A.
Strube, Wolfgang
Bunse, Tilmann
Falkai, Peter
Wobrock, Thomas
Impairments of Motor-Cortex Responses to Unilateral and Bilateral Direct Current Stimulation in Schizophrenia
title Impairments of Motor-Cortex Responses to Unilateral and Bilateral Direct Current Stimulation in Schizophrenia
title_full Impairments of Motor-Cortex Responses to Unilateral and Bilateral Direct Current Stimulation in Schizophrenia
title_fullStr Impairments of Motor-Cortex Responses to Unilateral and Bilateral Direct Current Stimulation in Schizophrenia
title_full_unstemmed Impairments of Motor-Cortex Responses to Unilateral and Bilateral Direct Current Stimulation in Schizophrenia
title_short Impairments of Motor-Cortex Responses to Unilateral and Bilateral Direct Current Stimulation in Schizophrenia
title_sort impairments of motor-cortex responses to unilateral and bilateral direct current stimulation in schizophrenia
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790105/
https://www.ncbi.nlm.nih.gov/pubmed/24109457
http://dx.doi.org/10.3389/fpsyt.2013.00121
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