Exogenous hormone use, reproductive history and risk of adult myeloid leukaemia

BACKGROUND: A hormonal aetiology is one explanation for the lower incidence of myeloid leukaemia in women compared with men. METHODS: In this population-based case–control study, we evaluated associations between exogenous hormone use and reproductive history and myeloid leukaemia, overall and by di...

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Detalles Bibliográficos
Autores principales: Poynter, J N, Fonstad, R, Blair, C K, Roesler, M, Cerhan, J R, Hirsch, B, Nguyen, P, Ross, J A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790163/
https://www.ncbi.nlm.nih.gov/pubmed/24002589
http://dx.doi.org/10.1038/bjc.2013.507
Descripción
Sumario:BACKGROUND: A hormonal aetiology is one explanation for the lower incidence of myeloid leukaemia in women compared with men. METHODS: In this population-based case–control study, we evaluated associations between exogenous hormone use and reproductive history and myeloid leukaemia, overall and by disease subtype. RESULTS: We observed a suggestive association between oral contraceptive use and acute myeloid leukaemia (odds ratio=0.55, 95% confidence interval=0.32–0.96). Hormone replacement therapy and reproductive factors were not associated with risk. CONCLUSION: Despite the biological plausibility for a role of oestrogen in leukaemogenesis, other aetiologic factors are likely to explain the differing incidence rates in males and females.

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