Exogenous hormone use, reproductive history and risk of adult myeloid leukaemia

BACKGROUND: A hormonal aetiology is one explanation for the lower incidence of myeloid leukaemia in women compared with men. METHODS: In this population-based case–control study, we evaluated associations between exogenous hormone use and reproductive history and myeloid leukaemia, overall and by di...

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Autores principales: Poynter, J N, Fonstad, R, Blair, C K, Roesler, M, Cerhan, J R, Hirsch, B, Nguyen, P, Ross, J A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790163/
https://www.ncbi.nlm.nih.gov/pubmed/24002589
http://dx.doi.org/10.1038/bjc.2013.507
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author Poynter, J N
Fonstad, R
Blair, C K
Roesler, M
Cerhan, J R
Hirsch, B
Nguyen, P
Ross, J A
author_facet Poynter, J N
Fonstad, R
Blair, C K
Roesler, M
Cerhan, J R
Hirsch, B
Nguyen, P
Ross, J A
author_sort Poynter, J N
collection PubMed
description BACKGROUND: A hormonal aetiology is one explanation for the lower incidence of myeloid leukaemia in women compared with men. METHODS: In this population-based case–control study, we evaluated associations between exogenous hormone use and reproductive history and myeloid leukaemia, overall and by disease subtype. RESULTS: We observed a suggestive association between oral contraceptive use and acute myeloid leukaemia (odds ratio=0.55, 95% confidence interval=0.32–0.96). Hormone replacement therapy and reproductive factors were not associated with risk. CONCLUSION: Despite the biological plausibility for a role of oestrogen in leukaemogenesis, other aetiologic factors are likely to explain the differing incidence rates in males and females.
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spelling pubmed-37901632014-10-01 Exogenous hormone use, reproductive history and risk of adult myeloid leukaemia Poynter, J N Fonstad, R Blair, C K Roesler, M Cerhan, J R Hirsch, B Nguyen, P Ross, J A Br J Cancer Short Communication BACKGROUND: A hormonal aetiology is one explanation for the lower incidence of myeloid leukaemia in women compared with men. METHODS: In this population-based case–control study, we evaluated associations between exogenous hormone use and reproductive history and myeloid leukaemia, overall and by disease subtype. RESULTS: We observed a suggestive association between oral contraceptive use and acute myeloid leukaemia (odds ratio=0.55, 95% confidence interval=0.32–0.96). Hormone replacement therapy and reproductive factors were not associated with risk. CONCLUSION: Despite the biological plausibility for a role of oestrogen in leukaemogenesis, other aetiologic factors are likely to explain the differing incidence rates in males and females. Nature Publishing Group 2013-10-01 2013-09-03 /pmc/articles/PMC3790163/ /pubmed/24002589 http://dx.doi.org/10.1038/bjc.2013.507 Text en Copyright © 2013 Cancer Research UK http://creativecommons.org/licenses/by-nc-sa/3.0/ From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
spellingShingle Short Communication
Poynter, J N
Fonstad, R
Blair, C K
Roesler, M
Cerhan, J R
Hirsch, B
Nguyen, P
Ross, J A
Exogenous hormone use, reproductive history and risk of adult myeloid leukaemia
title Exogenous hormone use, reproductive history and risk of adult myeloid leukaemia
title_full Exogenous hormone use, reproductive history and risk of adult myeloid leukaemia
title_fullStr Exogenous hormone use, reproductive history and risk of adult myeloid leukaemia
title_full_unstemmed Exogenous hormone use, reproductive history and risk of adult myeloid leukaemia
title_short Exogenous hormone use, reproductive history and risk of adult myeloid leukaemia
title_sort exogenous hormone use, reproductive history and risk of adult myeloid leukaemia
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790163/
https://www.ncbi.nlm.nih.gov/pubmed/24002589
http://dx.doi.org/10.1038/bjc.2013.507
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