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A phase II study evaluating the toxicity and efficacy of single-agent temsirolimus in chemotherapy-naïve castration-resistant prostate cancer

BACKGROUND: The mammalian target of rapamycin (mTOR) pathway is deregulated in castration-resistant prostate cancer (CRPC). We investigated the efficacy and toxicity of temsirolimus, an mTOR inhibitor, in chemotherapy-naïve CRPC. METHODS: In this phase II open label study, eligible patients received...

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Detalles Bibliográficos
Autores principales:	Kruczek, K, Ratterman, M, Tolzien, K, Sulo, S, Lestingi, T M, Nabhan, C
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2013
Materias:	Clinical Study
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790181/ https://www.ncbi.nlm.nih.gov/pubmed/24008662 http://dx.doi.org/10.1038/bjc.2013.530

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